|
|
The toxicity of vitamin D
Drouliskou, Eleftheria ; Mladěnka, Přemysl (advisor) ; Janoušek, Jiří (referee)
Vitamin D has essential role in skeletal health, however studies over the recent years have outlined its implication in many other physiological functions. The importance of vitamin D for health has, on one hand, raised needs for supplementation but may, on the other hand, lead to excessive administration. Vitamin D toxicity or hypervitaminosis D due to excess of vitamin D is a medical condition manifested mainly as hypercalcemia, with mostly gastrointestinal and neuropsychiatric symptoms. Long-term administration of large doses of vitamin D can result in vascular calcification and hence by associated with a cardiovascular risk. Hypervitaminosis D is extremely rare likely due to high therapeutic index of vitamin D. The clinical research shows an administration of 10.000 IU/day of vitamin D, which meets the criteria for the tolerable upper intake level, even for extended period, is probably not associated with adverse effects in almost all individuals in general population. However there are case studies globally showing vitamin D toxicity can occur due to misuse of over-the-counter vitamin D supplements, inappropriate prescribing or uncontrolled administration of high dose unlicensed preparations.
|
guest ::
