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Assessment of visual short-term memory binding and its role in the identification of subtle memory decline
Borovská, Šárka ; Horáková, Hana (advisor) ; Michalec, Jiří (referee)
The concept of memory binding appears to be auspicious for identification of subtle memory decline in early stages of Alzeheimer's disease (AD). Visual Short-Term Memory Binding Test (VSTMBT) is an experimental test of short-term visual memory binding, it assesses the binding condition (shape+colour) along with the control condition of short-term memory (shape only). Although the results of the current studies seem promising, a number of limitations are present (different versions of the test, small sample size, familial vs. sporadic form of AD, etc.). In this thesis, the VSTMBT was administered to a comprehesively defined sample of people without dementia from the Czech Brain Aging Study (N=161). When comparing the groups using analysis of variance with subsequent post hoc tests, it was found that the group with amnestic mild cognitive impairment (aMCI, n=56) performed the lowest compared to the group with subjective cognitive decline (SCD, n=60) and to the cognitively normal volunteers (CN, n=45). When controlling for the effect of age and gender, these differences persisted (aMCI < KN; aMCI < SCD) in the memory binding condition (for the two-item version). The performance of the SCD group did not differ from the KN. In the subset of patients with available biomarkers, performances were compared...
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