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National Repository of Grey Literature

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Study of Radiolabeling of PAMAM Dendrimers of 1st and 4th Generation with Diagnostic and Therapeutic Radionuclides Biricová, Veronika ; Lázníčková, Alice (advisor) ; Kafka, Petr (referee) ; Komárek, Pavel (referee) Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Candidate Mgr. Veronika Biricová Supervisor Doc. Ing. Alice Lázníčková, CSs. Title of Doctoral Thesis Study of radiolabeling of PAMAM dendrimers of 1st and 4th generation with diagnostic and therapeutic radionuclides. Treatment and diagnosis of diseases using radioactive isotopes is important field on which pharmaceutical research is focused. In order to obtain drug which would specifically bind to receptors released by cells of affected organs and tissues and concurrently provide them a high dosage of radiation, one part of research projects is focused on finding carriers and also new metal chelators suitable for binding in a high number on biologically active molecule. This dissertation thesis is focused on a research of a new bifunctional chelator of trivalent metal ions bound in a high number on a branched dendrimer. Different parameters evaluating suitability of chelator for bond creation with radioactive istotopes were reviewed. From the biggest part is this thesis focused on labeling of dendrimer macromolecules with ligands bound on their surface with three different radioactive isotopes. Success of the labeling under different conditions based on value of radiochemical purity... Detailed record

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