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Quinazoline derivatives as compounds with potential bronchodilatory effect III
Abo El Dahabová, Mona ; Špulák, Marcel (advisor) ; Vinšová, Jarmila (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Author: Mona Abo El Dahabová Supervisor: PharmDr. Marcel Špulák, Ph.D. Title of diploma thesis: Quinazoline derivatives as compounds with potential bronchodilatory effect III Asthma and COPD are serious diseases worldwide, that are mostly medicated with agents possessing bronchodilatory activity. Based on our previous research, I did prepare quinazoline derivatives via changing the structure of (-)vasicinone, which showed promising bronchodilatory activity. The reactions took place mainly by the mechanism of nucleophilic substitution, which is characterized with binding of the nucleophile to the appropriate molecular target. During my diploma thesis, I have isolated the quinazoline derivatives in the form of a tertiary amine and a quaternary ammonium salts. For most of the prepared substances, I determined their bronchodilatory activity at ex vivo rat trachea, which indicated possible direction of the structure modifications of the original compounds. Keywords: Asthma, COPD, muscarine receptors, (-)vasicinon, quinazolines, bronchodilatory activity.
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