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Intrauterine growth retardation (IUGR / SGA) - causes, clinical view, consequences
Kročilová, Kateřina ; Sedlak, Petr (advisor) ; Čermáková, Ivana (referee)
Deficient intrauterine growth may point to a serious health problem of fetus. It is associated with increased perinatal and neonatal mortality and morbidity. Long-term health consequences have been reported in IUGR / SGA children. There are many factors leading to intrauterine growth retardation. What is important is early diagnosis and distinction of children with prenatal growth deficiency (IUGR) and children constitutionally small for gestational age (SGA). This bachelor thesis summarizes basic knowledge of this disease and describes the various practices for the treatment of growth hormone.
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Quantification of differences in ossification zones hand TW3 method in patients with hypothyroidism - the possibility of diagnostic use
Daniš, Robert ; Sedlak, Petr (advisor) ; Čermáková, Ivana (referee)
The assessment of the development of skeletal maturation is an essential diagnostic tool in many pediatric disciplines, especially in pediatric endocrinology. The most accurate method of estimating bone age (KV) is a method of Tanner-Whitehouse 3 (TW3), which separately evaluates compartments RUS and CARP, the ossification is controlled by different hormonal axes. While the file type of long bones (metacarpals, phalanges of fingers and distal epiphysis of the radius and ulna - system RUS) is under the dominant influence of somatotropic axis, in the regulation of the development of carpal bones (system CARP) dominates the influence of thyroid axis. The proportionality developmental retardation of the two compartments from the chronological age can directly show the suspected endocrine cause of growth and developmental disorder. The study included 48 patients with subclinical form of hypothyroidism or in eufunctional status and a reference group of 65 patients with idiopathic growth hormone deficiency and 53 children with constitutional delay of growth and development. All patients were from pediatric ambulances of the Institute of Endocrinology in Prague, ranging in age from 4-18 years. Differences were observed in the value of KV RUS/CARP, height and chronological age and midparental and TW3...
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