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A study of directly compressible tableting materials with the combination of chitosan and silicified microcrystalline cellulose.
Rabasová, Markéta ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Markéta Rabasová Consultant: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of directly compressible tableting materials with the combination of chitosan and silicified microcrystalline cellulose This thesis deals with the study of compressibility of directly compressible tableting materials with chitosan and silicified microcrystalline cellulose Prosolv® SMCC 90 in a ratio of 3:1, their lubricant sensitivity and the tensile strength of tablets. Retardant components of the tableting materials are sodium alginate in concentrations of 30, 40 and 50 % or its combinations with hypromellose 15M in a ratio of 1:1 in the same concentrations. Magnesium stearate in a concentration of 1 % is used as a lubricant, indomethacin in a concentration of 20 % is used as a model drug. Tablets without the lubricant and the drug are compressed by compression forces of 3, 3,5 and 4 kN, tablets with the lubricant and the drug are compressed by compression force of 4 kN. T1-FRO 50 Zwick/Roell material testing equipment is used for the compression of the tablets. The compressibility is evaluated by the energy profile of the compression process, the lubricant sensitivity is evaluated by...
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A study of directly compressible tableting materials and tablets with chitosan.
Karešová, Eliška ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical Technology Student Eliška Fleglová Consultant doc. PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis A study of directly compressible tableting materials and tablets with chitosan. This thesis deals with the study of compressibility of directly compressible tableting materials with chitosan, their lubricant sensitivity and tensile strength of tablets. Other components of tableting materials are sodium alginate in a concentrations of 30, 40 and 50 %, or the combinations of sodium alginate and hypromellose 15M in the ratio of 1: 1 in the same concentrations. Magnesium stearate in a concentration of 1 % is used as a lubricant. Indomethacin in a concentration of 20 % is used as a model drug. Tablets without lubricant and without drug are compressed by compression forces 4, 4,5 and 5 kN, tablets with lubricant and with drug by compression force 4 kN using the material testing equipment T1- FRO 50 Zwick/Roell. The compressibility is evaluated by the energy profile of the compression process, sensitivity to lubricants by values lubricant sensitivity ratio. The total energy of compression increases with the compression force. It is the highest for chitosan alone. The addition of retardants decreases its values. The...
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Study of excipients' influence on the drug dissolution from tablets
Ouzký, Miroslav ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Supervisor: Consultants: Assoc. Prof. PharmDr. Zdeňka Šklubalová, Ph.D. Mgr. Jana Brokešová, Mgr. Daniel Pěček Student: Miroslav Ouzký Title of Thesis: Study of excipientsʼ influence on the drug dissolution from tablets The aim of this work was to study the influence of excipients on the dissolution of the high-dose active substance from tablets. The tablets were compressed from the granules prepared by wet-granulation method. 11 batches of tablets which contained two different fillers: either lactose or microcrystalline cellulose, respectively; and extragranularly added disintegrant: either croscarmellose or crospovidone, respectively, in three concentration levels of 2 %, 3,7 % or 5,4 % were prepared. Tablets were packed into aluminium/PVC blisters. The paddle dissolution test was used to determine the release of the active substance into phospate buffer pH 7,2 at the time of preparation (time 0) and at the time points 1.5, 3 and 6 months of stability assay at 40 řC and 75 % relative air humidity. The results show that the drug release from tablets containing microcrystalline celulose was generally faster than from those containing lactose. The same was true for tablets to which croscarmellose was...
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Adhesive and rheological properties of chitosan-based mixtures
Korpasová, Marie ; Šnejdrová, Eva (advisor) ; Mužíková, Jitka (referee)
CHARLES UNIVERSITY IN PRAGUE Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Name and surname: Marie Korpasová Title of diploma thesis: Adhesive and rheological properties of mixtures based on chitosan Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Diploma thesis deals with evaluation of rheological and adhesive properties of compounds for matrix tablets formulation, based on Chitosan with addition of retardant compound. The retardant compound consists of Sodium Alginate and Hypromellose in concentrations of 30 %, 40 % and 50 %. Theoretical part describes Chitosan, Sodium Alginate and Hypromellose. As next is division of matrix tablets. Theoretically is also described evaluation of rotational, oscillational and adhesive testing which was used in practical part. From viscosity curves can be seen, that viscosity is decreasing with increasing stress. Viscosity increases with increasing concentration of Sodium Alginate and Hypromellose. Oscillational testing is better for gel characterization, because it provides lower stress on test samples. Samples of given compound were prepared by hydrating with phosphate buffer of pH 6,8. Coefficient of consistency K and index flow rate n characterize rheological behaviour of gels. Viscoelastic compounds behave like solids with plastic...
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Adhesive and rheological properties of chitosan-based mixtures in media of different pH
Omar, Alaa Abdel Gawad Ahmed Osman ; Šnejdrová, Eva (advisor) ; Mužíková, Jitka (referee)
Title of thesis: Adhesive and rheological properties of chitosan-based mixtures in media of different pH Author: Alaa Omar Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Consultant: Mgr. Juraj Martiška The aim of the diploma thesis is the study of rheological and adhesive properties of tableting materials for matrix tablets based on chitosan. The theoretical part describes in detail the materials used to prepare the matrix tablets, which were chitosan, sodium alginate and hypromellose. The experimental section was focused on the flow and adhesive properties of the chitosan-based mixtures after exposing them to a media of different pH. The flow tests were done on an absolute rotational rheometer. Obtained viscosity curves were analysed by Power law model. Viscosity at 10 s-1 and Power Law model coefficients were used to evaluate and compare the flow behaviour of dispersions with different concentrations of retarding component in different media. The test of adhesion was carried out using a pull away test on a rotational rheometer and evaluated as maximal detachment force. The remarkably high viscosity of 5% dispersions at pH 1.2 is due to the dissolution of chitosan, as sodium alginate is not soluble in acidic media. The increase in viscosity with the concentration of the retarding component is insured...
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Study of excipients' influence on the drug dissolution from tablets
Ouzký, Miroslav ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Supervisor: Consultants: Assoc. Prof. PharmDr. Zdeňka Šklubalová, Ph.D. Mgr. Jana Brokešová, Mgr. Daniel Pěček Student: Miroslav Ouzký Title of Thesis: Study of excipientsʼ influence on the drug dissolution from tablets The aim of this work was to study the influence of excipients on the dissolution of the high-dose active substance from tablets. The tablets were compressed from the granules prepared by wet-granulation method. 11 batches of tablets which contained two different fillers: either lactose or microcrystalline cellulose, respectively; and extragranularly added disintegrant: either croscarmellose or crospovidone, respectively, in three concentration levels of 2 %, 3,7 % or 5,4 % were prepared. Tablets were packed into aluminium/PVC blisters. The paddle dissolution test was used to determine the release of the active substance into phospate buffer pH 7,2 at the time of preparation (time 0) and at the time points 1.5, 3 and 6 months of stability assay at 40 řC and 75 % relative air humidity. The results show that the drug release from tablets containing microcrystalline celulose was generally faster than from those containing lactose. The same was true for tablets to which croscarmellose was...
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A study of directly compressible tableting materials with the combination of chitosan and silicified microcrystalline cellulose.
Rabasová, Markéta ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Markéta Rabasová Consultant: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of directly compressible tableting materials with the combination of chitosan and silicified microcrystalline cellulose This thesis deals with the study of compressibility of directly compressible tableting materials with chitosan and silicified microcrystalline cellulose Prosolv® SMCC 90 in a ratio of 3:1, their lubricant sensitivity and the tensile strength of tablets. Retardant components of the tableting materials are sodium alginate in concentrations of 30, 40 and 50 % or its combinations with hypromellose 15M in a ratio of 1:1 in the same concentrations. Magnesium stearate in a concentration of 1 % is used as a lubricant, indomethacin in a concentration of 20 % is used as a model drug. Tablets without the lubricant and the drug are compressed by compression forces of 3, 3,5 and 4 kN, tablets with the lubricant and the drug are compressed by compression force of 4 kN. T1-FRO 50 Zwick/Roell material testing equipment is used for the compression of the tablets. The compressibility is evaluated by the energy profile of the compression process, the lubricant sensitivity is evaluated by...
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A study of directly compressible tableting materials and tablets with chitosan.
Fleglová, Eliška ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical Technology Student Eliška Fleglová Consultant doc. PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis A study of directly compressible tableting materials and tablets with chitosan. This thesis deals with the study of compressibility of directly compressible tableting materials with chitosan, their lubricant sensitivity and tensile strength of tablets. Other components of tableting materials are sodium alginate in a concentrations of 30, 40 and 50 %, or the combinations of sodium alginate and hypromellose 15M in the ratio of 1: 1 in the same concentrations. Magnesium stearate in a concentration of 1 % is used as a lubricant. Indomethacin in a concentration of 20 % is used as a model drug. Tablets without lubricant and without drug are compressed by compression forces 4, 4,5 and 5 kN, tablets with lubricant and with drug by compression force 4 kN using the material testing equipment T1- FRO 50 Zwick/Roell. The compressibility is evaluated by the energy profile of the compression process, sensitivity to lubricants by values lubricant sensitivity ratio. The total energy of compression increases with the compression force. It is the highest for chitosan alone. The addition of retardants decreases its values. The...
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Influence of fillers and disintegrants type on properties of tablets with high dose drug.
Tranová, Thao ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Consultant: doc. PharmDr. Jitka Mužíková, Ph.D. Student: Thao Tranová Title of Thesis: Influence of fillers' and disintegrants' type on properties of tablets with high dose drug The work engages in the study of fillers' and extragranular superdisintegrants' influence on properties of tablets with high dose drug. Two types of granulate with lactose or microcrystalline cellulose were produced in high shear granulator. Eleven tablets groups with different type and amount of superdisintegrants were prepared from the granulates. Tablets contained 2 %, 3.7 %, 5.4 % of sodium croscarmellose or 2 % and 5.4 % of crospovidone. The tested parameters of tablets were friability, hardness, disintegration time and density. Accelerated stability studies lasting 6 months at temperature of 40 řC and relative humidity 75 % were done. The tablets were evaluated after 1.5, 3 and 6 months. All tablets had adequate friability, hardness, disintegration and density at T0. Increasing concentration of superdisintegrant decreased disintegration time. Tablets containing microcrystalline cellulose and sodium croscarmellose disintegrated faster than tablets containing lactose or crospovidone. Tablets with sodium croscarmellose had...
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The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets.
Rumlerová, Lenka ; Ondrejček, Pavel (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Consultant: PharmDr. Pavel Ondrejček, Ph.D Student: Lenka Rumlerová Title of Thesis: The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets. This thesis deals with influence of rice extract, as a new kind of glidant on compressibility of microcrystalline celulose as a model filler. Furthermore it evaluates the impact of rice extract on tablet properties. Effects of rice extract were compared with two standard glidants - magnesium stearate and colloidal silicon dioxide. As first the influence of diferent glidants concetrations on flow properties of mixtures were assesed. Tablets were compresed using three different compression forces. A force- displacement record was used to evaluate the compressibility of microcrystalline cellulose and its mixtures with glidants. Subsequently, the properties of tablets were evaluated. The radial strenght, abrasion, and tablet disintegration time were measured. The results revealed that the rice extract has the least effect on mixtures flow poperties. However, all mixtures showed a statistically significant improvement in flowability. When using a 1 % rice extract, the flow properties of the...
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