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3D structures of phosphorylation
Kielarová, Anežka ; Novotný, Marian (advisor) ; Vařeková, Radka (referee)
Protein phosphorylation is a common post-translational protein modification used in almost all cellular processes. When a phosphate group is added to an amino acid side chain, it may alter the protein conformation and protein-protein interactions due to its size and its negative charge. It may also change the protein function, activity and even localization within the cell. Experimental detection of phosphorylation is still extremely labor demanding and very expensive, even when deploying protein mass spectrometry. For this very reason many bioinformatics scientific groups focus on the prediction of protein phosphorylation sites. Recent analyses of phosphorylation sites studied mainly non-phosphorylated phosphorylation sites and the distribution and representation of amino acids sequentially neighboring them. Since sequentially more distant, but structurally close amino acids can contribute to the recognition of protein substrate by protein kinase, structural environment of phosphorylation sites was studied in this thesis. Furthermore, 3D structures of phosphorylation sites were comprehensively studied for the first time in a phosphorylated state and the results were compared with the results obtained from the analysis of non- phosphorylated sites. Phosphorylation sites were found mostly within...
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Paper
Plášil, Ondřej ; Novotný, Martin (referee) ; Tobola, Ondřej (advisor)
The aim of this thesis is to create a portfolio of paper products with respect to established ethical principles. The resulting products must have a suitable design optimized for the manufacturing process. Based on the changes in sales over the past two decades, this work revises the current market position of paper. In addition, it generally examines the unethical communication of paper entities towards the end user. The result of this thesis is a range of products of two selected basic types - notebook and photo album. The overall results of my efforts, including this work, are likely to result in the creation of a new, own brand.
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Preparation and implementation of the construction of a kindergarten
Kubíček, Lukáš ; Novotný, Michal (referee) ; Diaz, Yvetta (advisor)
The aim of my thesis is the Construction technological project of nursery school building. The work involves technical report building equipment, technological instruction for selected activities, inspection and test plans, design of mechanical assemblies, transport links, schedule of health and safety, as well as environmental protection, itemized project budget, timetable and building maintenance instructions
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CONSTRUCTIONAL AND TECHNOLOGICAL PROJECT OF RECONSTRUCTION OF BUILDING ROOSEVELTOVA IN BRNO
Pavelka, Petr ; Nečasová, Barbora (referee) ; Novotný, Michal (advisor)
This diploma thesis deals with the constructional and technological project of reconstruction of building Rooseveltova in Brno. The basis for this work was the design documentation for the realization of this project. The technical reports provides all the basic information about the construction to this project. Demolition works and implementation of cast-in-place reinforced concrete floor are detailed processing in the technological regulations. Control and test plans, time and financial plans, drawings of building equipment, draft of machinery and plans of health and safety and fire prevention are also component of this project. Another annex of this thesis is budget and selected assembly details.
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Implementation of Proton Therapy Center in Prague
Halanič, Daniel ; Novotný, Michal (referee) ; Nečasová, Barbora (advisor)
The diploma thesis deals with the construction technological project of carcass SO – 001 Proton Therapy Center. The thesis is focused on part B (gantry) of hospital building Proton Therapy Center in Bulovka Hospital area in Prague. The thesis is being processed vertical and horizontal massive monolithic reinforced concrete skeleton realization. The thesis is report, budget, time schedule, technological specification, design of site equipment, design of machinery, design of road construction and next text and drawing documentation processed by assignment of diploma thesis.
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Building Construction Project - Implementation of Highway Overpass no. D1 - 150
Nováková, Martina ; Novotný, Michal (referee) ; Nečasová, Barbora (advisor)
This diploma thesis deals with demolition of the motorway overpass. The bridge (overpass) is located over the D1 motorway from Prag to Brno at the 115,881 km. On the brigde runs the local comunication II/352 between villages Švábka and Měšín. The bridge demolition is part of the D1 renovation plan. The main reason behind the demolitions si that the bridge no longer meets it´s lenght requierments. During the demolition and construction will be any use of II/352 for public transport over the bulding site forbiden. This diploma thesis include technical report for construction technology project, time and financial evaluation of the project. Also the thesis deals with the selected technological regulations of carried out activities, timetable of controls and tests, trafice relationships on wider scale, a list of main building machines and mechanisms with their specification, a concept of the construction site, health and safety requlations, and in detail plans for realization of a road surface layers.
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Hotel with wellness
Jagoš, Ondřej ; Tichomirov,, Vladimír (referee) ; Novotný, Miloslav (advisor)
The topic of this thesis is a new-building of a hotel with a wellness centre. The building site is located in the cadastral area of Malenovice near Zlín, the city of Zlín, Zlín Region. It is the building consisting of three rectangles inserted into each other. The building is designed as a six-floor skeletal construction with a cellar made of reinforced concrete, roofed with flat roofs. In the first floor there is a reception, a restaurant with outside seating, wellness centre, and utility rooms. The second and the third floor are intended for accommodation of guests in the form of double rooms and apartments. In the fourth and fifth floors there are double rooms as well. Rooms for guests and apartments are situated to the southern and northern part. This residential space is mostly equipped with balconies stretching along the corners. In the last, sixth floor there can be found the management of the hotel, a conference room and a bar with terrace. The main entrance is situated to the northern part of the object. Outdoor parking places are also a part of the hotel. Exterior and interior of the hotel are designed in the conformity with current modern trends. The layout of the space is functional and basic. The dynamics of the building is supported by external holes in black colour and by the two-coloured facade in blue and grey colours. The hotel is meant for both active and passive relaxation, there is a possibility of accommodation of young couples, families with children, elderly people, individuals, and people with limited ability of movement. The hotel of designed with the focus on the comfort of guests. Therefore the leisure time space is a part of hotel. The comfortable space for relaxation within the object is provided by the wellness centre mentioned above, the bar with terrace, and an outdoor swimming pool. The disposition of the object is fastened by the reinforced concrete monolithic panels and by the feet placed under both inside and outside reinforc
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Construction technology project of residential building in Frýdek
Jurečka, Matěj ; Venkrbec, Václav (referee) ; Novotný, Michal (advisor)
The subject of this diploma thesis is a construction technology project of a residential building in Frýdek. It is a residential building with four floors and a basement situated in Frýdek – Místek. The content of the preparation of technical reports for the construction and technological project studies and implementation of major technological stages. Creating a time and financial plan for a solved object. Further elaboration of technological regulations for drilled piles and reinforced concrete ceiling structure. A control and test plan is also being developed for these constructions. There is also a project site facility design and a machine assembly and a main lifting mechanism along with the occupational safety and health solution. In addition, the construction site is solved in connection with the transport routes. The thesis is designed with respect to the economic and time aspect.
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Construction Technology Project of University of Tomáš Baťa in Zlín
Krištof, Marek ; Novotný, Michal (referee) ; Venkrbec, Václav (advisor)
The subject of my diploma thesis is selected parts of the construction technology project of Tomas Bata University in Zlín. The content of the work is mainly elaborated technological regulation for making the monolithic ceiling shell of the main aula of the building, processing of the control and test plan and drawings of the ceiling shell. Next, I worked on the design of suitable transport routes to the construction site, the processing of the studies of the implementation of the main technological stages, the design and the processing of the drawings of the construction site, which varies in time depending on the progress of the technological stages, the design and assessment of the lifting mechanisms and machines, time and financial plan, the timetable for the rough construction and the main technological stages, budget of the rough construction, health and safety at work.
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Construction-technological project of the extension of the production hall
Mézl, Petr ; Liška, Pavel (referee) ; Novotný, Michal (advisor)
This diploma thesis deals with the construction and technological project of the extension of the production hall Granitol a.s. in Moravian Beroun. The thesis focuses on the technological stage of assembly of the prefabricated skeleton of the rough top structure and the laying of the floor formation. In addition, an extended accompanying and summary technical report, a technical report on transport relations and coordination of oversized transport, a time and financial plan for the construction, a budget for the prefabricated skeleton, a timetable and the balance of the workers, the design of the main construction machines and mechanisms, including their time commitment , organization of the construction of the building including drawings of the construction site equipment, technological regulation for the assembly of the prefabricated skeleton and the laying of the floor formation, inspection and testing plan for the prefabricated skeleton assembly, summary assessment of the lifting mechanism selection, schematic of the assembly procedure of the prefabricated skeleton elements, protection and health at work during construction.
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