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Clinical Content Harmonisation of Electronic Health Record
Nagy, Miroslav ; Říha, Antonín (advisor) ; Dostálová, Taťjana (referee) ; Veselý, Arnošt (referee)
Title: Clinical Content Harmonisation of Electronic Health Record Author: Mgr. Miroslav Nagy Department: Department of Medical Informatics, Institute of Computer Science v.v.i., Academy of Sciences of the Czech Republic Supervisor: RNDr. Antonín Říha, CSc. Supervisor's e-mail: riha@euromise.cz This PhD thesis deals with the possibilities of clinical content harmonisation in elec- tronic health records (EHR). In the first sections, the current state of the art in the field of EHR and other related fields is summarised, as well as that of the tools supported by current software technologies and the results of research in the field of medical in- formatics. The work is focused on analysis of obstacles in sharing medical data and on proposals of steps for overcoming these obstacles. Next, the utilized tools, modelling approaches, standards and coding systems used during the research are summed up. In the following sections the methods pointing to achieving harmonized clinical models are elaborated on and resulting clinical concepts mappings, supporting tools, developed EHR systems and semantic interoperability platforms are presented. In the conclusion these results are discussed and some future work is proposed. Keywords: electronic health record, semantic interoperability, clinical content, har-...
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název v anglickém jazyce není uveden
Fikáčková, Hana ; Navrátil, Leoš (advisor) ; Dostálová, Taťjána (referee) ; Rosina, Jozef (referee)
Temporomandibular joint disorders (TMD) are defined as a collective term embracing clinical problems that involve the masticatory musculature, the temporomandibular joint and associate stuctures. These disorders are primarily characterized by pain, joint sounds, and irregular or limited function. Other common complaints are headache, jaw-ache, ear-ache, facial pain or tinnitus [Chyba! Nenalezen zdroj odkazů.,Chyba! Nenalezen zdroj odkazů.,Chyba! Nenalezen zdroj odkazů.,Chyba! Nenalezen zdroj odkazů.]. Carlsson [Chyba! Nenalezen zdroj odkazů.] reported in a review of the epidemiologic literature that the need for treatment of TMD is with a range 5% and 13% among adults. At present, the majority of authors propose a multifactor aetiology for TMD, considering that acute trauma, degenerative articular disorders, psychological factors and functional mandibular overload are involved [Chyba! Nenalezen zdroj odkazů.,Chyba! Nenalezen zdroj odkazů.,Chyba! Nenalezen zdroj odkazů.,Chyba! Nenalezen zdroj odkazů.]. Although the diagnosis of TMD is based mainly on the detailed patient's history and clinical examination, in some cases it is necessary to complete these routine procedures through imaging methods that can help to find out the cause of a patient's pain [Chyba! Nenalezen zdroj odkazů.,Chyba! Nenalezen...
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Biological properties of titanium alloy coated with hydroxyapatite in relation to immediate implant loading
Seydlová, Michaela ; Dostálová, Taťjána (advisor) ; Racek, Jaroslav (referee) ; Jelínková, Helena (referee)
Coating dental implants with hydroxyapatite may give certain advantages such as active encouragement to new bone growth, a lower rejection rate and an improved long-term prosthesis fixation. The biological properties of dental implants coated by the sandwich technique with a thin layer of hydroxyapatite and an interlayer of zirconia were evaluated. The implant samples were covered by pulsed laser deposition. The aim of this study is to evaluate the cytotoxicity and the surface characteristics of the titanium targets modified with zirconia and hydroxyapatite. We used a direct test of cytotoxicity, tests of fibroblasts adhesion and proliferation using counting of harvested cells and providing a MTT assay. No changes in the morphology or the proliferation rate of the cells used were found in the presence of the modified titanium targets. The results show adhesion and cell proliferation, which in turn implies that the studied material is not cytotoxic and is suitable for cell colonization. Titanium modified with zirconia and crystalline hydroxyapatite can improve the biological properties and so can be benefitially employed in oral bone surgery. Powered by TCPDF (www.tcpdf.org)
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Biological and mechanical properties of titanium implant covered with hydroxyapatite and zirconia layers and the approach to the immediate loading of dental implants
Teuberová, Zuzana ; Dostálová, Taťjána (advisor) ; Racek, Jaroslav (referee) ; Jelínková, Helena (referee)
Dental implantology is a branch, which has started a rapid evolution over the last years. All of the experts dealing with implantation are focused on extending indications for the application of the used materials to reduce the time period of therapy. Coating of the implants is a possible way how to treat patients in a shorter time period with the similar results as following the classical Bránemark protocol.Hydroxyapatite is one of the most attractive materials for human hard tissue implants because of its close resemblance to the bone and the teeth. Its positive influence on the healing process called osseointegration is obvious. Hydroxyapatite is of a brittle nature and limits the applications as the main solid material for the dental implants. Zirconia ceramics have several advantages such as the high strength and it is frequently used to reinforce other ceramics. The concept of adding zirconia as the second phase to hydroxyapatite significantly increased the bonding strenght.In the dissertation pulsed laser deposition is shown as one of the coating method. The bioceramic zirconia samples were characterized by methods for thin solid film analysis such as X-ray diffraction, morfology investigation by electrone microscope and measurement of the film thickness. Afterwards we examined the mechanical...
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