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Single-stage steam turbine
Hrnčířová, Michaela ; Fiedler, Jan (referee) ; Novotný, Zdeněk (advisor)
This bachelor thesis deal with project for single-stage steam turbine specified to the steam reduction station combined thermal cycle. Involvement rotary reduction is elective, to was enough exploited steam power. For the specified parameters was proposed designed the acceptable conception of turbo-generator with a direct connection to an asynchronous generator. The most important part work is the thermodynamic calculation of the flow part whose aim is achieve maximum efficiency and operation of turbines. To increase in efficiency and on the basis engeged turns is considered using of bandage. Also is effected the choice of acceptable steam paddings.
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Processing Czech in Python
Novotný, Zdeněk ; Schmidt, Marek (referee) ; Smrž, Pavel (advisor)
This bachorelor´s thesis presents some ways of Czech language processing. The first part contains a general destription of NLTK system. Some of aftermentioned functions were inspired by NLTK functions. There are described functions which attend to inflection and inflexion of various words class in Czech language. Next part is focused on processing of the text in Czech language in which are found and marked each sentences and other parts. Last part describes possibillity of tranformations rules application for each part of text. Results after rules application could be represented graphically.
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Steam turbine
Morávek, Tomáš ; Novotný, Zdeněk (referee) ; Fiedler, Jan (advisor)
This Master’s thesis deals with the general principles of design and preliminary project work on the tender processing of small industrial, heating backpressure or condensing steam turbine, engine hall for the supplied turboset, perhaps even the other functional units attached to the turboset, such as cooling circuit, condensing system and output of the cable harnesses from the generator. This thesis does not include a condensate preparation, steam production for a new turbine or a measurement and regulation control system.
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Backpressure Steam Turbine
Chrástek, Pavel ; Novotný, Zdeněk (referee) ; Fiedler, Jan (advisor)
The diploma works demonstrates the thermodynamic calculation and design of the geometry flow profile of the back-pressure steam turbine for specified inlet and outlet conditions of steam. Next target of the work is to design the drawing of the turbine axial cross section. Structuring of this diploma work calculation is following: - regulating stage thermodynamic calculation - turbine stages calculation - equalizing-balancing piston calculation - entire turbine intrinsic efficiency and power rating determination - basic calculation of gearbox parameters and RENK-type gearbox selection for turbine and generator arrangement
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Repair of the turbine housing
Jelínek, Tomáš ; Novotný, Zdeněk (referee) ; Fiedler, Jan (advisor)
This diploma thesis deals with the repair of a steam backpressure single-stage turbine. This thesis is assigned to a specific Spilling turbine case. A revisional report of this turbine with repair or exchange suggestions of demaged turbine parts is processed. In addition, a simulation of the contact pressure is carried out on the split plane of the housing. Structural modifications are designed and simulated to increase the parting plane's tightness. Further, the calculation of the tightening torque of the split plane is performed and a control thermodynamic and strength calculation of the labyrinth seals is performed.
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The significance of ovarian cancer cell chemosensitivity testing.
Řezáč, Adam ; Tošner, Jindřich (advisor) ; Novotný, Zdeněk (referee) ; Chovanec, Josef (referee)
Ovarian cancer is a leading cause of death from gynecologic malignancies. Most ovarian carcinomas are diagnosed in an advanced stage. Surgical treatment promotes a high response rate combined with chemotherapy. However, two-thirds of patients experience a relapse, followed by a development of chemoresistance, and, subsequently, death. The biological diversity of individual types of ovarian carcinoma is so varied, that a single treatment regimen can not be considered as a fitting treatment for all patients. Various studies focus on the individualisation of cancer treatment. This study targets the in vitro sensitivity testing in ovarian carcinoma cells on cytostatics using the MTT test. We presume that this method could be utilised in clinical decision-making process. Between the years 2006 and 2010, we have acquired tumor tissue and malignant ascites from a total of 55 patients enrolled in our study and analyzed those samples in vitro for chemosensitivity / chemoresistance using the MTT test. The aim of this research work was to asses chemosensitivity of ovarian carcinoma cells and compare these results with clinical parameters. Carcinoma cells displayed in vitro chemosensitivity to cisplatin in 67% of patients. Tumor cells of 22% patients proved to be sensitive to carboplatin and 16% to paclitaxel....
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Communication FC Vysočina Jihlava with sports fans
Novotný, Zdeněk ; Voráček, Josef (advisor) ; Šíma, Jan (referee)
Thesis title: Communication FC Vysočina Jihlava with sports fans The new conception considering communication policy between FC Vysočina Jihlava plc and sports fans in a case of promotion to the first league is fundamental goal of this thesis. This concept is supposed to lead to improvement in the field of communication with sports fans. Complementary assignment is the analysis and evaluation of current situation in communication with fans. This relation is one of the crucial points of sports club management. The examination of current state of affairs is based not only on SWOT analysis, but also on results of marketing research. This research is another complementary task of this thesis. Keywords: FC Vysočina Jihlava, a.s, fans, communication, marketing, market research, SWOT analysis
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The Use of Immune Markers in the Managament of Preterm Birth
Korečko, Vladimír ; Novotný, Zdeněk (advisor) ; Roztočil, Aleš (referee) ; Měchurová, Alena (referee)
Structured summary Aim of the study: To compare the diagnostic reliability, accuracy, and safety of amniocentesis and amniotic fluid Interleukin-6 testing in the diagnosis of intrauterine inflammation of patients with preterm premature rupture of membranes. Type of study: Prospective cohort study Name and location of study site: Department of Gynaecology and Obstetrics, Faculty of Medicine, Charles University in Pilsen Set and methodology: We prospectively examined patients with pPROM between the 23rd and 34th week of gestation in 2014 - 2017. All of them underwent amniocentesis and determination of IL-6 levels in amniotic fluid, leukocytes and bacteria in amniotic fluid as well as maternal blood examination for inflammation parameters. The results were compared to histological examination of the placenta after delivery for the presence of chorioamnionitis. Based on the values mentioned above the sensitivity, specificity, negative and positive predictive value, false positive and negative predictive value and accuracy of the test were determined together with an assessment of statistical significance. Furthermore, the feasibility and incidence of perioperative complications as well as the risk of secondary infection when pregnancy continued were evaluated by serial aniocenteses at weekly intervals. The...
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Biomarkers of epithelial ovarian tumors and of the endometrium
Presl, Jiří ; Novotný, Zdeněk (advisor) ; Špaček, Jiří (referee) ; Fingerová, Helena (referee)
Structured abstract Study objectives: Ovarian carcinoma 1/ comparison of sensitivities among monitored markers CA 125, HE4, CA 19-9, CEA, TK, TPS, MonoTotal 2/ comparison of false positivity of markers CA 125 and HE4 3/ use of CA 125, HE4 and ROMA index in the diagnostics of ovarian carcinoma 4/ use of CA 125 and HE4 in the follow-up of ovarian cancer Endometrial carcinoma 1/ feasibility of use of biomarkers CA125 and HE4 in patients with endometrial cancer in pre- operative management Study design: Retrospective data analysis Settings: Department of Obstetrics and Gynecology, Medical Faculty and Teaching Hospital in Pilsen Patients and Methods: Ovarian cancer 1/ Sensitivity of markers CA 125, HE4, CA 19-9, CEA, TK, TPS, and MonoTotal was assessed in 266 patients - 19 with ovarian cancer and 247 with benign disorders. 2/ False positivity of markers CA125 and HE4 was evaluated in a total of 390 patients with benign diagnoses - 60 women with endometriosis, 70 pregnant patients, 67 patients with ascites, 60 with pleural effusion, 25 with cardiac failure , 80 with renal insufficiency and 28 with hepatic failure. 3/ As a part of this objective we evaluated 552 patients with abnormal pelvic abnormality - 30 women had a histologically confirmed malignant ovarian tumor. Other 522 women had a benign condition. The...
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Diagnosis and therapy of intrauterine pathologies associated with pregnancy.
Švabíková, Lucie ; Žižka, Zdeněk (advisor) ; Novotný, Zdeněk (referee) ; Kacerovský, Marian (referee)
Introduction: Actually 0.7-1 percent of all deliveries can be followed by secondary uterine bleeding. There is a residual trophoblastic tissue diagnosed in most of these cases and it is often managed by repeat intrauterine interventions. These operations are connected with high risk of formation of intrauterine adhesions and their early diagnosis and management can be important for next fertility. Material and methods: There were generally 188 patients included into the study. All patients underwent ultrasound examination in 6 weeks after delivery and ambulant hysteroscopy after next 2 months without anesthesia. Described intrauterine pathologies (residual tissue and adhesions) were managed in one step. Results: In cases with suspect ultrasound finding, the retained trophoblastic tissue was diagnosed by hysteroscopy in 66 percent vs. in 96 percent with sensitivity 85 percent and specificity 85 percent. Patients with intrauterine adhesions had normal ultrasound finding in 74 percent and it did not recognized patients with severe adhesions in 94 percent. Clinical signs had generally 72 percent of patients with diagnosed left residual tissue. Number of severe residual tissue is increasing with delay of instrumental evacuation from delivery (10 vs. 30 percent). When is necessary to repeat the operation...
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