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Antracyklinová antibiotika na bázi protilátkou směrovaného HPMA
Říhová, Blanka ; Strohalm, Jiří ; Jelínková-Ibrahimová, Markéta ; Kovář, Marek ; Šubr, Vladimír ; Etrych, Tomáš ; Mrkvan, Tomáš ; Šťastný, Marek ; Plocová, Daniela ; Šírová, Milada ; Hovorka, Ondřej ; Kubáčková, K. ; Ulbrich, Karel
Conjugates based on N-(2-hydroxypropyl)methacrylamide represent a new generation of polymeric anticancer drugs with improved therapeutic potential and considerably decreased nonspecific side effects. Antibody -targeted derivatives show specific active targeting and nonspecific passive accumulation in solid tumors.
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Protinádorová směrovaná léčba na bázi HPMA: základní principy pro syntézu konjugátů a převod z laboratoře do kliniky
Říhová, Blanka ; Strohalm, Jiří ; Prausová, J. ; Kubáčková, K. ; Jelínková, Markéta ; Rozprimová, L. ; Šírová, Milada ; Plocová, Daniela ; Etrych, Tomáš ; Šubr, Vladimír ; Mrkvan, Tomáš ; Kovář, Marek ; Ulbrich, Karel
Conjugates of N-(2-hydroxypropyl)methacrylamide with doxorubicin containing human IVIg were used for palliative treatment in patients with advanced cancer. More thena 116 biochemical and immunological parameters were tested. A decrease of some parameters with patological values was seen, and physiological values were occasionally reached, including some TAA.
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India in the World Trade Organization
Jelínková, Markéta ; Štěrbová, Ludmila (advisor) ; Zamykalová, Miroslava (referee)
The Bachelor Thesis addresses to India and its treatment within the World Trade Organization. Authoress is concerned with Indian trade policy, stressing the tariffs issue, the analysis of Indian approach to the negotiations about trade liberalization and its stances to the agriculture, industrial production, services and intellectual property rights. She construes also Indian disputes in the World Trade Organization and tries to determine if deeper trade liberalization would be beneficial for this country.
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