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National Repository of Grey Literature 22 records found  beginprevious21 - 22  jump to record: Search took 0.00 seconds. 
Mechanismus působení polymerních léčiv na bázi HPMA
 Hovorka, Ondřej ; Strohalm, Jiří ; Bouček, Jan ; Etrych, Tomáš ; Šubr, Vladimír ; Ulbrich, Karel ; Říhová, Blanka
However cytostatic polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are in clinical trials, we are still far away from understanding the mechanism of their action. Cleavability of the drug from oligopeptidic side-chains of polymeric carriers seems not to be necessary condition for pharmacological activity and those spacers play most probably a very important role in the accumulation of conjugates in tumor cells.
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Protinádorová směrovaná léčba na bázi HPMA: základní principy pro syntézu konjugátů a převod z laboratoře do kliniky
 Říhová, Blanka ; Strohalm, Jiří ; Prausová, J. ; Kubáčková, K. ; Jelínková, Markéta ; Rozprimová, L. ; Šírová, Milada ; Plocová, Daniela ; Etrych, Tomáš ; Šubr, Vladimír ; Mrkvan, Tomáš ; Kovář, Marek ; Ulbrich, Karel
Conjugates of N-(2-hydroxypropyl)methacrylamide with doxorubicin containing human IVIg were used for palliative treatment in patients with advanced cancer. More thena 116 biochemical and immunological parameters were tested. A decrease of some parameters with patological values was seen, and physiological values were occasionally reached, including some TAA.
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National Repository of Grey Literature : 22 records found   beginprevious21 - 22  jump to record:
See also: similar author names
2 Šubr, Vojtěch
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