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Prognostic indicators of risk of death and the consequences of purulent meningitis
Džupová, Olga ; Janovská, Daniela (advisor) ; Křížová, Pavla (referee) ; Marešová, Vilma (referee) ; Dostál, Václav (referee)
Purulent meningitis is a life-threatening acute infectious disease of the central nervous system. In preantibiotics period was almost one hundred percent fatality rate of disease, with the discovery of antibiotics and their introduction into medical practice in 30th-50th of the last century has decreased dramatically. In recent decades, despite the use of highly effective antibiotics and intensive care procedures, there was no significant reduction in mortality rate and consequences of the disease. Lethal course of the disease affects 15-30% of patients in adulthood. Although not a common infection diagnosis among the top ten infectious causes of death worldwide. The study was based on evaluation of their own group of patients to determine prognostic factors observed history, course of illness and laboratory characteristics of the clinical outcome of disease in adults.
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Tick-borne rickettsial diseases: emerging risks in Europe
Veselá, Petra ; Janovská, Daniela (advisor)
Ricekttsiae are small, gram negative bacteria, known as an etiologic agens of many human as well as animal diseases. The course of rickettsial infections extremely differs in severity. Bacteria are transmitted via arthropodes, infected dust, milk and secretions of infected individuals. Thank to the better hygienical standards many rickettsial infections appear only in the developing countries. On the other hand some other rickettsial infections have higher incidency in atypical countries and ecosystems. This change is thought to be due to global warming. The importance of early diagnosis and proper therapy is common to all infections
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