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National Repository of Grey Literature

22 records found  13 - 22  jump to record:

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	Protinádorová účinnost konjugátu na bázi N-(2-hydroxypropyl)metakrylamidu, obsahujícího doxorubicin a normální lidský imunoglobulin Šírová, Milada ; Strohalm, Jiří ; Rossmann, Pavel ; Mrkvan, Tomáš ; Šubr, Vladimír ; Plocová, Daniela ; Ulbrich, Karel ; Říhová, Blanka Polymeric conjugate based on HPMA containing cytotoxic drug (doxorubicin) and human “non-specific” immunoglobulin has a significant anti-tumour effect and does not impair immune functions of the host. C57BL/6 mice with EL-4 lymphoma, when completely cured with the conjugate, were protected against the same tumour due to a specific anti-tumour immune reaction Detailed record
	Polycationic graft copolymers as carriers for oligonucleotide delivery Koňák, Čestmír ; Reschel, Tomáš ; Šubr, Vladimír ; Ulbrich, Karel ; Dautzenberg, H. ; Zintchenko, A. Polycationic graft copolymers as carriers for oligonucleotide delivery. Detailed record
	Enzymatically degradable drug carrier system based on poly(ethylene glycol) multiblock copolymers Pechar, Michal ; Šubr, Vladimír ; Ulbrich, Karel ; Seymour, L. W. Detailed record
	Vliv aplikace protrahované formy lecirelinu na ovariální struktury hospodářských zvířat Sedlák, J. ; Sedláková, J. ; Ulbrich, Karel ; Šubr, Vladimír Detailed record
	Hydrolytically degradable hydrogels for controlled release of drugs Ulbrich, Karel ; Šubr, Vladimír ; Burešová, Marie ; Šrogl, Jan ; Říhová, Blanka Detailed record
	Využití protrahované lékové formy superanalogu LH-RH k přerušení sezonního anestru ovcí a koz Sedlák, L. ; Sedláková, J. ; Ulbrich, Karel ; Šubr, Vladimír Detailed record
	Diffusion of PHPMA polymers in brain extracellular space Vargová, Lýdia ; Kubinová, Šárka ; Tao, L. ; Ulbrich, Karel ; Šubr, Vladimír ; Nicholson, C. ; Syková, Eva The movement of bulky PHPMA polymers through ECS is limited in contrast to linear PHPMA macromolecules which have the same ability to explore ECS as small molecules. Detailed record
	Antracyklinová antibiotika na bázi protilátkou směrovaného HPMA Říhová, Blanka ; Strohalm, Jiří ; Jelínková-Ibrahimová, Markéta ; Kovář, Marek ; Šubr, Vladimír ; Etrych, Tomáš ; Mrkvan, Tomáš ; Šťastný, Marek ; Plocová, Daniela ; Šírová, Milada ; Hovorka, Ondřej ; Kubáčková, K. ; Ulbrich, Karel Conjugates based on N-(2-hydroxypropyl)methacrylamide represent a new generation of polymeric anticancer drugs with improved therapeutic potential and considerably decreased nonspecific side effects. Antibody -targeted derivatives show specific active targeting and nonspecific passive accumulation in solid tumors. Detailed record
	Mechanismus působení polymerních léčiv na bázi HPMA Hovorka, Ondřej ; Strohalm, Jiří ; Bouček, Jan ; Etrych, Tomáš ; Šubr, Vladimír ; Ulbrich, Karel ; Říhová, Blanka However cytostatic polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are in clinical trials, we are still far away from understanding the mechanism of their action. Cleavability of the drug from oligopeptidic side-chains of polymeric carriers seems not to be necessary condition for pharmacological activity and those spacers play most probably a very important role in the accumulation of conjugates in tumor cells. Detailed record
	Protinádorová směrovaná léčba na bázi HPMA: základní principy pro syntézu konjugátů a převod z laboratoře do kliniky Říhová, Blanka ; Strohalm, Jiří ; Prausová, J. ; Kubáčková, K. ; Jelínková, Markéta ; Rozprimová, L. ; Šírová, Milada ; Plocová, Daniela ; Etrych, Tomáš ; Šubr, Vladimír ; Mrkvan, Tomáš ; Kovář, Marek ; Ulbrich, Karel Conjugates of N-(2-hydroxypropyl)methacrylamide with doxorubicin containing human IVIg were used for palliative treatment in patients with advanced cancer. More thena 116 biochemical and immunological parameters were tested. A decrease of some parameters with patological values was seen, and physiological values were occasionally reached, including some TAA. Detailed record

National Repository of Grey Literature : 22 records found   13 - 22  jump to record:

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2	Šubr, Vojtěch

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