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Voltammetric determination of anticancer drug flutamide at screen-printed carbon electrodes
Vyskočil, V. ; Navrátil, Tomáš ; Barek, J.
Flutamide, 4-nitro-3-trifluoromethyl-isobutylanilide, is the active component of a synthetic nonsteroidal antiandrogen drug, which is commonly used in the treatment of advanced prostate cancer. In this contribution, optimum conditions have been found vor voltammetric determination of flutamide by DC voltammetry (DCV) and differential pulse voltammetry (DPV) at screen-printed carbon electrodes (SPCEs). Under optimum conditions (Britton-Robinson buffer pH 7.0 - methanol (9:1)), linear calibration curves were measure with limits of quantification 6x10(-7) molL(-1) and 8x10(-7) molL(-1) for DCV at SPCEs, respectively. The newly developed methods were successfully applied to the determination of the drug in pharmaceutical formulation Apo-Flutamide (Eulexin tablets).
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Amperometric Determinations of Nitrocompounds with Flow Detector of Silver Solid Amalgam
Yosypchuk, O. ; Barek, J. ; Josypčuk, Bohdan
In this pilot study, a new type of flow tubular amperometric detector based on silver solid amalgam was introduced. The tubular cell was tested under flow injection analysis for determination of 4-nitrophenol in aqueous solutions. The first results show that this type of detector provides high-quality signals of 4-nitrophenol. However, there are some problems with repeatability of signals caused probably of high sensitivity due to the presence of oxygen, which we shall try remove in further research.
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Electrochemical detection of trace amounts of nitrated explosives
Barek, J. ; Fischer, J. ; Vyskočil, V. ; Pecková, K. ; Navrátil, Tomáš ; Josypčuk, Bohdan
Nitrated organic compounds belong to the group of the most frequently used explosives. Detection of low levels of such compounds is very attractive in these days. Due to the easy reducibility of the nitro group, voltammetry seems to be very suitable method for these purposes. For these determinations the following electrodes were used: were used hanging mercury drop electrode, meniscus modified silver solid amalgam electrode, miniaturized paste silver amalgam electrode, paste electrode on the basis of silver amalgam powder and proper organic liquid were used.
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Voltametrické stanovení sloučenin dusíku pomocí stříbrné pevné amalgámové elektrody
Daňhel, A. ; Barek, J. ; Josypčuk, Bohdan ; Pecková, K.
Silver amalgam is a good electrode material for construction of new types of electrodes. In this work a silver solid amalgam paste electrode was prepared. The pastes were mixed from a silver solid amalgam powder and a mineral oil, silicone oil, paraffin oil and tricresylphosphate, stuffed into a Teflon body of electrode. The silver paste amalgam electrodes are expected to provide new possibilities for determinations of electrochemically reducible compounds by modern voltammetric methods. The main expected advantage is the possibility of easily renewable surface as in the case of carbon paste electrodes.
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Composite solid amalgam electrodes
Lukina, A. ; Josypčuk, Bohdan ; Navrátil, Tomáš ; Pecková, K. ; Barek, J.
Preparation and first results achieved by composite silver solid amalgam electrodes (AgSA-CE) are presented. Polished, film as well as mercury meniscus modifications of these electrodes were studied by determination of p-nitrophenol, lead, cadmium, iodades, adenine, ascorbic acid and other compounds.
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Determination of herbicide dinoseb with amalgam and carbon electrodes
Fischer, J. ; Barek, J. ; Pecková, K. ; Zima, J. ; Kücükkolbasi, S. ; Ersöz, M. ; Kara, H. ; Josypčuk, Bohdan ; Navrátil, Tomáš
Dinoseb, systematically 2-(1-methylpropyl)-4,6-dinitro-phenol, is phenolic, commonly used herbicide and insecticide. Dinoseb has two very easy reducible nitro-groups in its structure and one electrochemically oxidizable hydroxy group. Differential pulse voltammetry was applied for its determination in water. The nitro group reduction was used for voltammetric determination with hanging mercury electrode (HMDE), mercury film electrode (MFE) and modified carbon paste electrode (MCPE) and carbon paste electrode (CPE) as well as meniscus modified silver solid amalgam electrode (m-AgSAE).
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