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Laboratory diagnostics of kidney injury in patients with diabates mellitus I and II.
Múčková, Ľubica ; Dršata, Jaroslav (advisor) ; Tichý, Aleš (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Ľubica Múčková Supervisor: Prof. MUDr. Jaroslav Dršata, CSc. Consultant: Ing. Jana Netriová, PhD. Title of diploma thesis: Laboratory diagnostics of kidney injury in patients with diabetes mellitus I and II Diabetes mellitus is a chronic metabolic disease. This disease leads to develompement of both microvascular and macrovascular complications. In this work we examined a microvascular complication - diabetic nephropathy - and its laboratory diagnostics. We focussed on parameters cystatin C and creatinine. We estimated a glomerular filtration with Grubb, Stevens and MDRD equations. The Grubb and Stevens equations use cystatin C to determine the glomerular fitrlation rate (GFR), MDRD equations use creatinine, albumin and urea. For the asessment of kidney function we evaluated albumin and total protein waste in urine samples collected for 24 hours. The parameters were measured in file of 183 patients. Number of pacients with diabetes I.type was 49 and with diabetes II.type was 134. The main intention of this work was to evaluate equations used for determination of GFR, to compare their pros and cons and put them in contrast with albumin and total proteins waste. In case of the patients...
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The Multilevel Marketing Management Strategy
Tichý, Aleš ; Ing.Zdeněk Kubišta (referee) ; Kocmanová, Alena (advisor)
This work deals with the "phenomenon" of today and multilevelovým marketing (MLM). The first part explains the MLM system and then compared with the "classic" business from the perspective of the functioning, organization and management control. The second part describes the specific MLM company, including assessment of SWOT analysis. At the end of this thesis are suggested possible solutions to sustain growth provided by the product or service.
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