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Use of vestibular rehabilitation in patients after stroke
Vícenová, Veronika ; Slámová, Adéla (advisor) ; Kozel, Jakub (referee)
BACHELOR THESIS ABSTRACT Author: Veronika Vícenová Supervisor: Ing. Bc. Adéla Slámová Title: Use of vestibular rehabilitation in patients after stroke Abstract: The thesis focuses on the application of Vestibular Rehabilitation Therapy (VRT) in the treatment of Cerebrovascular accident (CVA). Annually, on average 50 thousand patients are hospitalised when diagnosed with CVA, of those only 25 % do not suffer the consequences and fully recover to their former health. Vestibular disorders account for one of the consequences of CVA. Patients suffer from dizziness, imbalance and the fear of falling down. To compensate for the deficiencies, VRT could be availed to improve stability, dizziness intensity, lower the risk of falling, ultimately leading to patient's social and occupational activity return. The thesis constitutes theoretical and practical parts. The former part is divided into 4 sections. The first section discusses the issue of CVA. The second one describes the vestibular system. The third section provides an insight to findings of VRT. The last section summarises the key concepts of postural stability. The practical part contains case history of three patients diagnosed with CVA and related balance disorders. Special rehabilitation program reflecting VRT principles was designed based on patients'...
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The influence of belinostat inhibition on the activity of selected reductases from AKR and SDR superfamilies.
Slámová, Adéla ; Wsól, Vladimír (advisor) ; Macháček, Miloslav (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Adéla Slámová Supervisor: prof. Ing. Vladimír Wsól, Ph.D. Title of diploma thesis: The influence of belinostat inhibition on the activity of selected reductases from AKR and SDR superfamilies Anthracycline antibiotics (ANTs) are important antineoplastic agents. One of them, daunorubicin (DAUN), is used for the treatment of acute leukaemia and other malignancies in children and adults. Factors limiting its clinical use include mainly resistance and cardiotoxicity. Enzymes from aldo-keto reductase (AKR) and short-chain dehydrogenase/reductase (SDR) superfamilies mediated the reduction of DAUN to its C-13 alcohol metabolite daunorubicinol (DAUNOL). The metabolite is more cardiotoxic, less antineoplastic, and is causing anthracycline resistance. This diploma thesis aimed to examine the inhibitory effect of belinostat on the activity of AKR1A1, 1B1, 1B10, 1C3, and CBR1. The specific enzyme activity and inhibitory potential were estimated in vitro using recombinant enzymes, and the enzymatic production of DAUNOL was evaluated by the liquid chromatography (UHPLC) system. The inhibition was decreased in order AKR1C3 AKR1B10 AKR1A1 AKR1B1 CBR1. The most inhibited enzyme, AKR1C3, expressed 50,7%...
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Attitude to rehabilitation and exercise in people with multiple sclerosis
Šmejkalová, Barbora ; Novotná, Klára (advisor) ; Slámová, Adéla (referee)
BACHELOR THESIS ABSTRACT Author: Barbora Šmejkalová Supervisor: Mgr. Klára Novotná, Ph.D. Consultant: Ing. Karolína Jakovcová Title: Attitude to Rehabilitation and Exercise in People with Multiple Sclerosis Abstract: The bachelor thesis adresses the attitude of patients with multiple sclerosis to rehabilitation and exercise. This bachelor thesis consists of theoretical and practical parts. The theoretical part includes a brief description of this disease and describes several possibilities of physiotherapy of multiple sclerosis. It also discusses the motivation of patients to exercise and appropriate physical activities. The practical part is based on a questionnaire survey conducted on the basis of a completed study in the MS Center at the Department of Neurology of the First Faculty of Medicine and General University Hospital in Prague. Data obtained from the rehabilitation questionnaire and the Godin-Shephard Leisure-Time Physical Activity questionnaire are processed in the form of tables and graphs. The aim of this work is to find out the patients' attitude to rehabilitation and exercise. I was interested in what motivates patients to physical activity and exercise, or what limits or prevents it. I also focused on monitoring the relation of demographic parameters to physical activities. The results...
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The Possibilities of Using Exoskeletal Suit Ekso GTTM in Physiotherapy with Spinal Cord Injury Patients
Smolej, Július ; Pětioký, Jakub (advisor) ; Slámová, Adéla (referee)
OF BACHELOR THESIS Autor: Július Smolej Vedoucí práce: Mgr. Jakub Pětioký, DiS. Title of bachelor thesis: The Possibilities of Using Exoskeletal Suit Ekso GTTM in Physiotherapy with Spinal Cord Injury Patients Abstract of bachelor thesis: This bachelor thesis is focused on how exoskeletal suit Ekso GTTM can be utilized in physical therapy with spinal cord injury patients during their rehabilitation stay in RÚ Kladruby. Theoretical part of the thesis is based on literature review and reflects issues of spinal injuries, their epidemiology, clinical manifestation, examination, separate phases of spinal damage, treatment and health consequences. Furthermore, the theoretical part of this thesis deals with possibilities of hi-tech robotic technologies and their usage in rehabilitation, especially focused on lower limbs, where exoskeletal suit Ekso GTTM belongs. The practical part of this bachelor thesis is divided into two sections. First section consists of patient's case studies using exoskeletal suit Ekso GTTM that are supposed to assess therapeutic benefits in use of this robotic machine. The second section contains evaluation of retrospectively gathered information from therapies undergone with Ekso GTTM since 2014 until 2019. Evaluation will be shown graphically and using excel tables. Key words:...
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Possibilities for the use of physiotherapy approaches in correction of university students'stress postural attitude. Subtitle: The comparison of compensatory exercise and apparatus therapy
Benešová, Lucie ; Slámová, Adéla (advisor) ; Jeníček, Jakub (referee)
BACHELOR THESIS ABSTRACT Author: Lucie Benešová Supervisor: Ing. Bc. Adéla Slámová Title: Possibilities for the use of physiotherapy approaches in correction of university students' stress postural attitude Subtitle: The comparison of compensatory exercise and apparatus therapy Abstract: This bachelor thesis examines the current issue of overloading young population due to overuse of modern technologies and permanent exposure of non-ergonomic spine positions. The bachelor thesis is divided into a theoretical and a practical part. The theoretical part explains terms such as posture, postural stabilization and stability. The faulty posture, the cause and the consequences are described in detail. Furthermore, the section summarizes the existing literature on posture diagnostics, ergonomics and prevention. The practical part processes four university student case reports on the subject's posture. The main method of data collection was rating by Klein, Thomas and Mayer. The aim of this study is to compare the effects of compensatory exercise with those of device therapy Upright Go on students with faulty posture. The main finding of this study is that compensatory exercise has a greater positive effect on posture than device therapy. Key words: Posture, muscle dyscoordination, ergonomics, compensatory exercise,...
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Risk Analysis of a Weldment Production Process
Slámová, Aneta ; Kurucová, Šárka (referee) ; Blecha, Petr (advisor)
This diploma thesis is focused on the risk analysis of a selected production process of the company SIK METAL s.r.o. The work is divided into three parts, the theoretical part, then the analysis of the current state and the design part. The theoretical part defines the basic concepts that relate to risks. These theoretical findings are then applied in the second part of the work, where risk identification is performed using various types of analysis. Based on selected analyzes, proposals and recommendations are proposed in the final part of the diploma thesis. Proposals and recommendations contain financial quantifications.
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The Effect of Vibration Platform on the Postural Stability of Patients after Stroke
Schönová, Kristýna ; Táborská, Silvie (advisor) ; Slámová, Adéla (referee)
The bachelor's thesis deals with the effect of the vibration platform on postural stability in patients who have sustained a stroke. It is divided into a theoretical and practical part. The theoretical part analyses terms: Stroke, postural stability, vibration and its effects. The practical part describes therapy and initial and exit examinations on two patients in a chronic stage of cerebrovascular accident. The initial and exit examinations were performed using medical history, casuistry, and assessment on posturography machine from the Synapsys company. Both the static and dynamic component of stability were assessed. The therapy alone was conducted on a vibration plate from Capital Sports company. The results were evaluated in the form of charts and graphs in the practical part of the thesis and tests in which both patients simultaneously showed the best results were selected.
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Comparison of stability evaluation tests for patients after brain damage from physiotherapist point of view
Timková, Tereza ; Jeníček, Jakub (advisor) ; Slámová, Adéla (referee)
Title of bachelor thesis: Comparison of stability evaluation tests for patients after brain damage from physiotherapist point of view Abstract: This bachelor's thesis deals with comparison of stability evaluation tests for patients after brain damage. The thesis is divided into theoretical and practical part. The theoretical part describes cerebrovascular accident, postural stability, and tests on assessment of stability. Tests on assessment of stability of patients after brain damage from the point of basic characteristics and parameters are compared in the practical part. At the same time, three case stories of patients, whose stability was assessed by selected tests, are provided: Berg Balance Scale, Mini- BESTest, and Tinetti Performance Oriented Mobility Assessment. Testing was done at the beginning and at the end of the rehabilitation program, after four-week interval. Results were analysed and compared subsequently. The thesis describes the importance of knowledge of the individual testing parameters to be able to assess whether condition of the patient has improved or deteriorated. Key words: stability, stroke, stability tests, measurement properties (clinimetric properties)
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The benefit of therapy with Gloreha glove at patients with central hemiparetic limb
Koscielniak, Martin ; Hoidekrová, Kristýna (advisor) ; Slámová, Adéla (referee)
Title: The benefits of therapy wiht Gloreha glove at patient with central hemiparetic limb Abstract: The bachelor thesis deals with the usage of Gloreha robotic system in the process of rehabilitation of patients who experienced stroke with hemiparesis of the upper limb. The work is both theoretical and practical. In the theoretical part is described the kinesiology of the upper limb, the problem of stroke and the usage of the robotic systems of Gloreha in the process of rehabilitation. The practical part is based on case studies of four patients with a diagnosis of stroke in the age between 18 to 59 years. Each proband underwent ten therapies over two weeks. The case reports include entry and departure kinesiological examinations. The aim of the work is to evaluate the therapeutic benefits of the Gloreha. To assess the effect was used the MAS spasticity rate, the Motor Index and the active range of motion. Three out of four patients noticed an improvement in their spasticity level according to MAS scale in at least one of the observed segments and also an improvement in the active range of motion in the metacarpofalnagial joints of the hand or an improvement in the active motility of the hemiparetic upper limb. In Motoricity index has been improved the strength of the upper limb in three out of four...
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Analysis of ergonomic sitting position and design of ergonomic seat for hemiparetic patients
Benešová, Karolína ; Slámová, Adéla (advisor) ; Šebek, Milan (referee)
BACHELOR THESIS ABSTRACT Author: Karolína Benešová Supervisor: Ing. Bc. Adéla Slámová Consultant: Ing. Petr Havlena Title: Analysis of ergonomic sitting position and design of ergonomic seat for hemiparetic patients Abstract: This bachelor thesis deals with sitting ergonomics and summarizes basic parameters of ergonomic chair, which are created for patients with hemiparesis. The bachelor thesis is divided into theoretical and practical part. In the theoretical part is described in detail the vascular supply of the brain, vascular disease, stroke and its clinical images. Furthermore, the concept of ergonomics is explained and the ergonomics of sitting are taken into account. The parameters for the ergonomic chair are based on the THERAPIA chair, so it is introduced in the theoretical part. In the practical part are processed two case reports of hemiparetic patients, which describe their sedation. The aim of this work is to create basic parameters of ergonomic chair for hemiparetic patients, which are based on studied ergonomics of the sitting and from the examination performed in patients. Key words: ergonomics, sitting position, stroke, chair
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