|
|
Ecological and phylogenetic effects determining variation of growth patterns in amniotes
Stanková, Veronika ; Frýdlová, Petra (advisor) ; Vohralík, Vladimír (referee)
Growth is a process during which organs or the whole body enlarges. It can be modeled by using growth models and curves. The work is mainly focused on the explanation of two types of growth - the determinate growth, which is finished after the reaching of the sexual maturity, and the indeterminate growth which on the other side continues even after the reproduction or after the reaching of the sexual maturity. In the literature there is generally stated that birds and mammals are characterized by the determinate growth, amphibians and reptiles have the indeterminate growth. The aim of this work was to analyze the current available literature relevant to the growth and to evaluate the above mentioned statements about the growth of the vertebrates. The ecological and the phylogenetic effects influencing the growth, the physiological regulation and the mechanism of the growth are summarized in this work. Powered by TCPDF (www.tcpdf.org)
|
|
|
Catechins: Interaction with Human Serum Albumin and Affecting its Glycation by Methylglyoxal
Staňková, Veronika ; Boušová, Iva (advisor) ; Dršata, Jaroslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Mgr. Veronika Staňková Supervisor: PharmDr. Iva Boušová, Ph.D. Title of thesis: Catechins: interaction with human serum albumin and affecting its glycation by methylglyoxal. The catechins (flavan-3-ols) are polyphenolic substances of higher plants exerting a wide spectrum of biological and pharmacological properties. The first part of this thesis was focused on the study of potential interactions of four catechins (namely (-)-catechin, (-)-gallocatechin, (-)-catechin gallate, and (-)-gallocatechin gallate) with human serum albumin (HSA). HSA is the main transport protein in the blood serum, which influences the metabolism, bioavailability and biological activity of drugs in vivo. Binding ability of catechins to HSA was evaluated in vitro using UV/VIS spectroscopy, fluorescence spectroscopy, and gel electrophoresis (native and SDS-PAGE). Binding ability of catechins to HSA varied depending on their chemical structure and concentration. The presence of galloyl moiety and number of hydroxyl groups were found to be key structural features essential for catechin interaction with the molecule of HSA. In the second part of this work, the ability of catechins to influence methylglyoxal-induced...
|
|
| |
|
| |
|
| |
|
| |
|
| |
guest ::
RSS feed.