|
|
Autophagy in yeast
Nejedlý, Adam ; Palková, Zdena (advisor) ; Libus, Jiří (referee)
Autophagy is a process of degradation of the cell cytoplasm, proteins, and organelles. It appears mainly as a response to a lack of nutrients or damage of cell structures and components. Yeast Saccharomyces cerevisiae and also Komagataella phapphi are the main model organisms for the research of autophagy. Autophagy is classified by two main criteria. Firstly, we divide autophagy into macroautophagy and microautophagy. During macroautophagy, the phagophore vesicle, called the autophagosome, is created around sequestrated cargo and then fuses with the vacuole. Microautophagy is a process in which a vacuolar membrane directly surrounds and sequester degraded cargo. During non-selective (bulk) autophagy, a random non- specific portion of cytoplasm is degraded. On the other hand, selective autophagy serves as a pathway for the degradation of specific proteins and organelles. Autophagy research has nowadays a great medical significance thanks to the role of autophagy defects in a wide area of human diseases.
|
|
| |
|
|
Swimming pool
Nejedlý, Adam ; Bartolšicová, Eva (referee) ; Matějka, Libor (advisor)
The aim of this master's thesis is design of an indoor swimming pool in the town of Náměšť nad Oslavou. The thesis contains project documentation, technical reports, reports of fire safety and assessment of building physics. There are two swimming pools designed in the building, main swimming pool of lenght 25m and a smaller one for children. Next to the pool hall a wellness area is placed consisting of three saunas, as well as cooling pool and a rest room. The proposed building has one ground floor and one basement level. Load-bearing structures are made of reinforced concrete except for the structure of the roof in the pool hall which is constructed from glued timber trusses. A glass facade is designed in this part of the building. Perimeter walls are thermally insulated using polystyrene foam. The roof is designed as a compact roof with foam glass thermal insulation.
|
|
|
Family house
Nejedlý, Adam ; Svobodová, Sylvia (referee) ; Matějka, Libor (advisor)
This bachelor thesis is focused on a design of a single-family house suitable for four to five permanent residents. The object is situated on an almost flat-surfaced lot on Růžičkova street in Třebíč. The house has two above ground floors and one underground floor. Plan dimensions of the house are 15,85 x 11,85 m. A garage for single vehicle is a part of the building. The roof is constructed as a single flat roof. The object is designed using a technology of Porotherm system except from the basement perimeter walls made of concrete blocks. The thesis also provides a project documentation for a construction including five constructional details, fire safety, thermal engineering, and acoustic solutions. The project documentation had been elaborated in an educational version of ArchiCAD program.
|
guest ::
RSS feed.