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Molecular mechanisms of Wnt signalling in mammalian cells
Lukáš, Jan ; Kořínek, Vladimír (advisor) ; Kohoutová, Milada (referee) ; Macůrková, Marie (referee)
Wnt signalling represents an important mechanism participating in control of cellular and developmental processes, including establishment of cell polarity, cell fate specification, stem cell self-renewal, tissue patterning and organogenesis, homeostasis maintenance and regeneration. Misregulation of the Wnt signalling during embryogenesis leads to developmental defects while aberrant activation later in development is associated with degenerative diseases and a number of cancers. The presented PhD thesis is based on four original publications that deal with the post-translational modifications of Wnt ligands and molecular mechanisms contributing to the regulation of a transcriptional profile of the so-called canonical Wnt pathway. Wnt signalling pathway is used repetitively both in time and different cellular contexts throughout development of multicellular organisms. Inevitably, in each single situation -catenin/TCF complexes, the downstream effectors, induce only subsets of all potential target genes. How this differential tissue- and stage-specific control over various subsets of target genes is achieved with such a limited number of nuclear effectors is not fully understood. Along with the expression of specific LEF/TCF family members or their variants containing different functional domains...
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Reception of Bedřich Smetana's Operas in Jan Malát's Arrangements
Lukáš, Jan ; Ottlová, Marta (advisor) ; Gabrielová, Jarmila (referee)
The thesis called Reception of Bedřich Smetana's operas in Jan Malát's arrangements deals with the typical phenomenon of 19th century musical life, e.g. music mediation in the form of arrangements. The thesis concentrates on a promoter Jan Malát and his arrangements of Bedřich Smetana's music. Jan Malát's arrengements played a substantial part in spreading Smetana's work. The thesis researches into Malát's nature of musical arrangements in relation to the original compositions of Smetana's operas. It also concentrates on changes in the society leading towards increase of demand for accessible music as far as the difficulty of interpretation is concerned. Based on the research of Bedřich Smetana's opera works reception, the thesis endeavours to describe reasons for publishing particular arrangements.
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How non-price factors affect the attendance of the Museum of Eastern Bohemia in Hradec Králové?
Lukas, Jan ; Rotschedl, Jiří (advisor) ; Chytil, Zdeněk (referee)
This thesis analyses non-price factors influencing the attendance of the Museum of Eastern Bohemia in Hradec Králové. On the basis of daily data, from 05/2011 to 05/2013, using average daily temperature, total daily precipitation, marketing, work and school holidays and individual months, three models were construed -- a model of total attendance, attendance of adults and attendance of children and students. Research has proven expected negative influence of temperature through all three models. Furthermore, there was a strong positive influence of school and work holidays. The results have also shown almost 50% increase of student attendance during holidays. Similarly, attendance of adults increases even more during non-working days. Marketing was studied in different ways but its statistically relevant influence has been proved only in the groups of children and students. Their attendance increases by quarter during campaigns.
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