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Czech healthcare in relation to doctors in hospitals
Kadlecová, Kristýna ; Háva, Petr (advisor) ; Tušková, Eva (referee)
Czech healthcare in relation to doctors in hospitals Kristýna Kadlecová Abstract In recent decades, researches focused on doctors attend to the fact that the "unhappy doctors" became a worldwide phenomenon. In the Czech Republic dissatisfaction was publicly revealed in connection with the strike of doctors. The problem that is amplified after transformation are poorly thought out, unilaterally oriented changes in the organizational arrangements that have an impact on hospitals and by extension, as well as a physician. Doctors perform the economic and managerial role in addition to medical one. The key issue is how physicians perceive these pressures and how it affects their working conditions. The aim of this research work is discontent of contemporary Czech doctors working in hospital, i.e. the causes of conflict between their expectations and reality of their labor and other conditions, as developed in the last 20 years, and especially in the last 2 years when there was a radicalization of representation of interests of hospital doctors in the country. In the empirical part is used qualitative research method - semi-structured interviews with physicians. Based on the research, we can observe a situation which devalues the profession of doctor and patient is also affected, which leads into other problems....
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The role of macrophages in immunosuppression mediated ny regulatory T cells
Kadlecová, Kristýna ; Holáň, Vladimír (advisor) ; Stříž, Ilja (referee)
Regulatory T cells (Treg) represent one of the most important mechanisms of immunoregulation. Treg suppress immune reactions and prevent overactivation of the immune system. There is a lot of ways of Treg action described, here we have focused on Treg interference with macrophages. The suppressor capacity of a highly purified Treg population was demonstrated in proliferation assays. The level of suppression of effector T cell proliferation differs depending on the presence of macrophages in the culture. Treg suppression has been significantly higher in the presence of macrophages. These observations led to hypotesis that Treg affect directly macrophages. However, using flow cytometry, reduction of expression of costimulatory molecules on macrophages after culture with Treg was not observed. Macrophages precultured with Treg showed a comparable functionality as macrophages cultured alone. Neither flow cytometry nor live cell imaging revealed any cytotoxic activity of Treg towards macrophages. Despite the presence of macrophages, Treg did not suppress effector cell proliferation in a model, where stronger activation of effector cells was induced. Therefore, a new hypothesis was presented - initially observed higher suppression in the presence of macrophages was probably caused by a qualitatively or...
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Choice of Marketing Strategy of the Selected Fitness
Kadlecová, Kristýna ; Pernica,, Martin (referee) ; Hanušová, Helena (advisor)
The main topic of this bachelor´s thesis is about choosing the marketing strategy for FITKO ABC company. The thesis is divided into the parts. First part introduces the theoretical solutions. In the second part the daily records and evaluation of the survey, which was the basis for a SWOT analysis and brand building strategy, was done. Proposed solutions were based on the collected data and analysis.
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