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Markers of Oxidative Stress are Elevated in Workers Exposed to Nanoparticles
Pelclová, D. ; Ždímal, Vladimír ; Fenclová, Z. ; Vlčková, Š. ; Schwarz, Jaroslav ; Pušman, Jan ; Zíková, Naděžda ; Syslová, K. ; Kuzma, Marek ; Navrátil, Tomáš ; Zakharov, S. ; Kačer, P.
Health-effects of nanoparticles in humans are little understood. Pre-shift and post-shift spirometry, markers in exhaled breath condensate (EBC), and fractional exhaled nitric oxide (FeNO) were measured both in 20 workers exposed to TiO2 aerosol and 19 controls. Particle number size distributions were monitored by aerosol spectrometers SMPS and APS, covering the overall size range 15 nm-10 μm. Simultaneously, the spatial distributions of total particle number and mass concentrations were determined using a particle number concentration monitor (P-TRAK) and a monitor of particle mass concentrations (DustTRAK DRX). Total aerosol concentrations in the production plant varied greatly in both space and time; number concentrations 1x104-2x105 particles/cm3 and mass concentrations 0.1-30 mg/m3. In the workshops, 90% of the particles were smaller than 100 nm in diameter and particle concentrations were 10x higher than in the control room.
Plný tet: SKMBT_C22013111914100 -  PDF
Plný text: content.csg - PDF
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