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A study of tableting materials and tablets with the combination of microcrystalline celulose and mannitol for orally disintegrating tablets.
Novotná, Andrea ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Andrea Novotná Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the combination of microcrystalline cellulose and mannitol for orally disintegrating tablets This thesis compares co-processed dry binder Avicel® HFE-102 containing 90 % microcrystalline cellulose and 10 % mannitol with a physical mixture of related dry binders, microcrystalline cellulose (Avicel® PH-102) and mannitol (Pearlitol® 100SD) in the ratio of 9:1. Flow properties, compressibility, lubricant sensitivity, tensile strength and disintegration time of tablets are evaluated. Compressibility is evaluated by means of the energy profile of compression process, and lubricant sensitivity by means of the lubricant sensitivity ratio. The results are also compared with the microcrystalline cellulose for direct compression Avicel® PH-102 alone. The flow properties of the co-processed dry binder Avicel® HFE-102 alone and the physical mixture were comparable. Avicel® HFE-102 showed higher values of the energy of plastic deformation, tensile strength of tablets, and a markedly lower lubricant sensitivity than the physical mixture of dry binders. Tablets with the...
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A study of the coprocessed dry binder with mannitol, lactose, dextrose and crospovidone for orally disintegrating tablets.
Bímová, Daniela ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Daniela Bímová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of the coprocessed dry binder with mannitol, lactose, dextrose and crospovidone for orally disintegrating tablets. This work evaluates and compares directly compressible tableting materials and tablets with Disintequik® ODT, which is used for the production of orodispersible tablets. The effect of three lubricants in two concentrations (0.5 and 1 %) on the properties of tableting materials and tablets is evaluated. Tested lubricants are magnesium stearate, calcium stearate and sodium stearyl fumarate. The tested parameters are flow properties, further compressibility, ejection force, tensile strength and disintegration time of tablets in the dependence on compression force. The compressibility is evaluated by the energy profile of the compression process. The lubricants improved the flowability of Disintequik® ODT and the best values were in the case of calcium stearate. The total energy of the compression increased with the compression force and the highest values were seen in the tableting materials with magnesium stearate. The values of plasticity decreased with the compression force. The ejection...
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Effect of compaction pressure on the compressibility of Neusilin US2 and polyethylene glycol mixtures
Svobodová, Aneta ; Vraníková, Barbora (advisor) ; Mužíková, Jitka (referee)
1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Candidate: Aneta Svobodová Supervisior: PharmDr. Barbora Vraníková, Ph.D. Title of Diploma Thesis: Effect of compaction pressure on the compressibility of Neusilin US2 and polyethylene glycol mixtures The liquisolid systems are modern preparations, that are capable to release a poorly soluble drug from the dosage form faster and thus increase its biovailability. The main principle of their preparation is conversion of the drug in the liquid state to a dry, non-adhesive powder with suitable flow properties allowing the subsequent formation of tablets or capsules. The aim of this diploma thesis was to determine the effect of compaction pressure on the tablets parameters (mass uniformity, height and diameter, hardness, friability, disintegration time and pycnometric density) prepared from mixtures containing different ratio of Neusilin US2 and polyethylene glycol 200. It was found that the best parameters were observed in tablets compressed using higher forces (2.0 and 2.5 kN). Compression forces of 0.5 and 1.0 kN led to the preparation of compacts with insufficient mechanical resistence. Mixture containing 60 % PEG 200 was selected as the best one as it implied the highest volues hardness...
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Homogenization of powder blends using a Turbula mixer.
Litošová, Martina ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
1 Abstract Charles University, Faculty of Pharmacy in Hradci Králové Department of: Department of Pharmaceutical Technology Supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph. D. Consultant PharmDr. Karel Palát, CSc., Mgr. Žofie Trpělková Student: Martina Litošová Title of Thesis: Homogenization of powder blends using a Turbula mixer. In this experimental work, the influencing of the homogeneity of the powder mixture of acetylsalicylic acid (ASA) and microcrystalline cellulose (Avicel PH102) due to the rotational speed of the mixing container in a range of 23−101 rpm, and the mixing time was studied using the Turbula shaker mixer. Within time interval 2-62 minutes, the content of ASA in samples was measured by near-infrared spectrometry. The expression of standard deviation was used to evaluate the homogeneity of samples. The best results were detected at a rotational speed of 34 rpm within time interval of 14−30 min.
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A study of tableting materials and tablets with the combination of microcrystalline celulose and mannitol for orally disintegrating tablets.
Novotná, Andrea ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Andrea Novotná Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the combination of microcrystalline cellulose and mannitol for orally disintegrating tablets This thesis compares co-processed dry binder Avicel® HFE-102 containing 90 % microcrystalline cellulose and 10 % mannitol with a physical mixture of related dry binders, microcrystalline cellulose (Avicel® PH-102) and mannitol (Pearlitol® 100SD) in the ratio of 9:1. Flow properties, compressibility, lubricant sensitivity, tensile strength and disintegration time of tablets are evaluated. Compressibility is evaluated by means of the energy profile of compression process, and lubricant sensitivity by means of the lubricant sensitivity ratio. The results are also compared with the microcrystalline cellulose for direct compression Avicel® PH-102 alone. The flow properties of the co-processed dry binder Avicel® HFE-102 alone and the physical mixture were comparable. Avicel® HFE-102 showed higher values of the energy of plastic deformation, tensile strength of tablets, and a markedly lower lubricant sensitivity than the physical mixture of dry binders. Tablets with the...
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A study of the coprocessed dry binder with mannitol, lactose, dextrose and crospovidone for orally disintegrating tablets.
Bímová, Daniela ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Daniela Bímová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of the coprocessed dry binder with mannitol, lactose, dextrose and crospovidone for orally disintegrating tablets. This work evaluates and compares directly compressible tableting materials and tablets with Disintequik® ODT, which is used for the production of orodispersible tablets. The effect of three lubricants in two concentrations (0.5 and 1 %) on the properties of tableting materials and tablets is evaluated. Tested lubricants are magnesium stearate, calcium stearate and sodium stearyl fumarate. The tested parameters are flow properties, further compressibility, ejection force, tensile strength and disintegration time of tablets in the dependence on compression force. The compressibility is evaluated by the energy profile of the compression process. The lubricants improved the flowability of Disintequik® ODT and the best values were in the case of calcium stearate. The total energy of the compression increased with the compression force and the highest values were seen in the tableting materials with magnesium stearate. The values of plasticity decreased with the compression force. The ejection...
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The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets.
Rumlerová, Lenka ; Ondrejček, Pavel (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Consultant: PharmDr. Pavel Ondrejček, Ph.D Student: Lenka Rumlerová Title of Thesis: The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets. This thesis deals with influence of rice extract, as a new kind of glidant on compressibility of microcrystalline celulose as a model filler. Furthermore it evaluates the impact of rice extract on tablet properties. Effects of rice extract were compared with two standard glidants - magnesium stearate and colloidal silicon dioxide. As first the influence of diferent glidants concetrations on flow properties of mixtures were assesed. Tablets were compresed using three different compression forces. A force- displacement record was used to evaluate the compressibility of microcrystalline cellulose and its mixtures with glidants. Subsequently, the properties of tablets were evaluated. The radial strenght, abrasion, and tablet disintegration time were measured. The results revealed that the rice extract has the least effect on mixtures flow poperties. However, all mixtures showed a statistically significant improvement in flowability. When using a 1 % rice extract, the flow properties of the...
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A study of compressiblity and properties of tablets from coprocessed dry binder with manntol and croscarmellose sodium for orodispersible tablets.
Kamarýtová, Martina ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Martina Kamarýtová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of compressibility and properties of tablets from coprocessed dry binder with mannitol and croscarmellose sodium for orodispersible tablets. This thesis deals with the study of directly compressible tableting materials and tablets with Parteck® ODT, which is designed for orodispersible tablets. The effect of three lubricants on the properties of tableting materials and tablets is evaluated. Tested lubricants are magnesium stearate, calcium stearate and sodium stearyl fumarate in concentrations of 0,5 and 1 %. Flow properties, compressibility, ejection force, tensile strength and disintegration time of tablets are tested. The compressibility is evaluated by the energy profile of compression process. Lubricants did not improve the flowability of Parteck® ODT. The total energy of compression increased with compression force and highest values were at the tableting material with 0,5 % magnesium stearate. The values of plasticity decreased with compression force, highest values were at the tableting material with 0,5 % sodium stearyl fumarate. The ejection force increased with compression force, the...
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A study of directly compressible tableting materials and matrix tablets with polyvinyl alcohol.
Vildová, Lucie ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Lucie Vildová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis A study of directly compressible tableting materials and matrix tablets with polyvinyl alcohol This work evaluates and compares the properties of directly compressible tableting materials and matrix tablets containing the combination of α-lactose monohydrate and microcrystalline cellulose in the ratio of 3:1 in a physical mixture and in a coprocessed dry binder. Polyvinyl alcohol is used as the retarding agent at the concentrations of 30, 40 and 50 %. Tested parameters are compressibility, tensile strength of tablets and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Dissolution testing is performed using rotating basket method. The values of total energy of compression, plasticity and tensile strength of the tablets were higher in the tableting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. The dissolution behavior of tablets, which contained physical mixture or coprocessed dry...
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Study of bulk and consolidation properties of size fractions of anhydrous lactose
Dostálová, Eliška ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Supervisor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Ing. Hana Hurychová Student: Eliška Dostálová Title of Thesis: Study of bulk and consolidation properties of size fractions of anhydrous lactose The bulk and consolidation behaviour of pharmaceutical excipients belong to their important properties. Properties of five size fractions of anhydrous lactose having the particle size in the range of 1-400 µm were studied in this thesis. The measurement was carried out by using static and dynamic pharmacopoeial methods. The bulk density and the tapped density, the angle of repose were evaluated as well as the true density of particles by using the gas pycnometry. The mass flow rate through the orifice of a model conical hopper by the force of gravity was estimated for the individual size fractions. The discharge rate through the orifice having the diameter in a range of 0.6-1.5 cm was modelled with the Beverloo et al and Jones < Pilpel power regression equations; the precision of the flow rate prediction was about 3 %. The best bulk properties were detected for the particle size fraction 246 µm. The results of the evaluation of the consolidation dynamic during the tapping of powder bed permitted...
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