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Early esophageal neoplasia: etiology, pathophysiology, pathogenesis and treatment. Barrett's esophagus and early esophageal adenocarcinoma
Krajčíová, Jana ; Martínek, Jan (advisor) ; Dolina, Jiří (referee) ; Bureš, Jan (referee)
Background: Barrett's esophagus (BE) is a premalignant condition defined by replacement of normal esophageal squamous-cell epithelium by cylindrical epithelium with intestinal metaplasia (IM). Patients with BE associated neoplasia (BORN) are candidates for endoscopic treatment. The aims of our studies were: (1) analysis of long-term efficacy of radiofrequency ablation (RFA) and evaluation of risk factors for persistent/ recurrent neoplasia/ IM; (2) to assess the results and safety of confocal laser endomicroscopy (CLE) compared to standard biopsies in patients after successful endoscopic treatment of BORN; (3) to assess the sampling quality obtained by different types of forceps; and (4) to assess "de novo" reflux after peroral endoscopic myotomy (POEM) and its severity (the risk of development of further complications). Patients and methods: We performed a total of 4 studies. (1) In a retrospective RFA study we evaluated data of 136 patients treated endoscopically for BORN in 4 centers in the Czech Republic. (2) In a prospective, pathologist-blinded, CLE study, we evaluated concordance in the detection of IM or neoplasia with CLE compared to standard biopsies in 56 patients who underwent standard surveillance endoscopy. (3) In a prospective study comparing 4 types of forceps, we evaluated the...
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Giuseppe Tartini and His Influence on the Development of Violin Playing
Krajčiová, Jana ; Tomášek, Jiří (advisor) ; Kubátová, Gabriela (referee)
Giuseppe Tartini is one of the most important personalities in the history of violin playing and literature. His rich heritage has contributed to the development of both, and his influence has crossed afar the Italian borders. This diploma thesis brings a complex view into the life and creation of this 18th century violin virtuoso. His composing activity uprose from his master violin skills, and therefore he composed especially for this instrument. Tartini transmitted his knowledge to the students of paduan School of nations, which he himself had founded. His treatise on ornaments Traité des agréments, compiled of the practical comments on the ornament interpretation, is of great significance. No small attention deserves also his letter to the pupil Maddalena Lombardini. As a matter of fact, it is a violin lesson in a letter form, and the value of the letter is by no means just historical. Another area of Tartini's interest was music theory, in which he invented so called difference tones. His contribution to the development of violin bow is also praiseworthy; he made several adaptations which brought the bow nearer to its current shape.
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Giuseppe Tartini and His Influence on the Development of Violin Playing
Krajčiová, Jana ; Tomášek, Jiří (advisor) ; Kubátová, Gabriela (referee)
Giuseppe Tartini is one of the most important personalities in the history of violin playing and literature. His rich heritage has contributed to the development of both, and his influence has crossed afar the Italian borders. This diploma thesis brings a complex view into the life and creation of this 18th century violin virtuoso. His composing activity uprose from his master violin skills, and therefore he composed especially for this instrument. Tartini transmitted his knowledge to the students of paduan School of nations, which he himself had founded. His treatise on ornaments Traité des agréments, compiled of the practical comments on the ornament interpretation, is of great significance. No small attention deserves also his letter to the pupil Maddalena Lombardini. As a matter of fact, it is a violin lesson in a letter form, and the value of the letter is by no means just historical. Another area of Tartini's interest was music theory, in which he invented so called difference tones. His contribution to the development of violin bow is also praiseworthy; he made several adaptations which brought the bow nearer to its current shape.
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