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Legal regulation of experimental animals handling
Kapoun, Jiří ; Stejskal, Vojtěch (advisor) ; Franková, Martina (referee)
Legal regulation of experimental animals handling This thesis deals with the legal regulation of experimental animals handling and their protection in international law, European union law and national law. Its goal is to complexly capture current legislation in this field, point out unsystematic or otherwise unsuitable institutes and propose means of their change. The core of the thesis is a description and an analysis of relevant parts of the Act on Animal Protection Against Cruelty, directives and regulations of the European Union and international treaties. Furthermore the thesis includes a treatise on the legal status of an animal, a brief introduction into ethical issues of animal experiments, historical evolution of relevant legal regulation and questions of administrative and criminal liability in the field of experimental animals handling.
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Molecular mechanisms of circadian clock entrainment by daily regime in food intake
Kapoun, Jiří ; Sumová, Alena (advisor) ; Červená, Kateřina (referee)
Circadian clocks form an endogenous time-keeping system present in most organisms, synchronizing physiological and behavioural processes with perodically changing environmental conditions. The system comprises of the master clock in the suprachiasmatic nuclei of the hypothalamus and numerous subsidiary clocks in peripheral tissues. Its molecular design is constituted by the clock genes, which are rhythmically expressed, form a series of transcriptional/translational feedback loops and influence the expression of various other genes involved in metabolic pathways. The peripheral clocks are dependent on the master clock, although they can be entrained with external cues like food intake timing and diet composition. This desynchronization leads to the distruption of clock gene oscillation, which can potentially have serious impact on metabolic processes and increase the risk of metabolic disorders. The aim of this thesis is to summarize current knowledge on the relationship of molecular chronobiology and nutrition with a focus on the molecular mechanisms through which can food, especially its intake timing and composition, influence the crosstalk between clock gene expression and cellular metabolism. The thesis also emphasises the potential effect of circadian clock disruption on the risk of metabolic...
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Legal regulation of experimental animals handling
Kapoun, Jiří ; Stejskal, Vojtěch (advisor) ; Franková, Martina (referee)
Legal regulation of experimental animals handling This thesis deals with the legal regulation of experimental animals handling and their protection in international law, European union law and national law. Its goal is to complexly capture current legislation in this field, point out unsystematic or otherwise unsuitable institutes and propose means of their change. The core of the thesis is a description and an analysis of relevant parts of the Act on Animal Protection Against Cruelty, directives and regulations of the European Union and international treaties. Furthermore the thesis includes a treatise on the legal status of an animal, a brief introduction into ethical issues of animal experiments, historical evolution of relevant legal regulation and questions of administrative and criminal liability in the field of experimental animals handling.
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