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Growth in children after allogenic hematopoetic stem cell transplantation
Tomešová, Jitka ; Sedlak, Petr (advisor) ; Keslová, Petra (referee)
Nearly 80 % of child oncological patients survive treatment nowadays and live in adulthood. Therefore, one of the main current children's oncology task is not only to cure the patient but to assure the life after treatment in as highest quality as possible. Related to the quality of life is the adequate adult body height which is in these children after hematooncological treatment ussualy known as impaired. The aim of this diploma thesis was to specify the frequency and level of impaired final body height in children after hematopoietic stem cell transplantation, and find its relation to sex, diagnosis and age at the time of transplantation. Thesis criteria met 89 children (35 female), who recieved the hematopoietic stem cell transplantation between years 1989 and 2012 in University Hospital in Motol, Prague. Children were observed prospectively in Laboratory of Clinical Anthropology of the Pediatric Clinic of University Hospital in Motol since the date of their transplantation till they reach their final body height. Each survey consists of the measurement of body height and weight, BMI calculation, Tanner pubertal stages and bone age assessment by the TW3 method. These, completed by clinical data about diagnosis, growth hormone deficiency treatment, and menarche in girls, were compared to the...
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Growth in children after allogenic hematopoetic stem cell transplantation
Tomešová, Jitka ; Sedlak, Petr (advisor) ; Keslová, Petra (referee)
Nearly 80 % of child oncological patients survive treatment nowadays and live in adulthood. Therefore, one of the main current children's oncology task is not only to cure the patient but to assure the life after treatment in as highest quality as possible. Related to the quality of life is the adequate adult body height which is in these children after hematooncological treatment ussualy known as impaired. The aim of this diploma thesis was to specify the frequency and level of impaired final body height in children after hematopoietic stem cell transplantation, and find its relation to sex, diagnosis and age at the time of transplantation. Thesis criteria met 89 children (35 female), who recieved the hematopoietic stem cell transplantation between years 1989 and 2012 in University Hospital in Motol, Prague. Children were observed prospectively in Laboratory of Clinical Anthropology of the Pediatric Clinic of University Hospital in Motol since the date of their transplantation till they reach their final body height. Each survey consists of the measurement of body height and weight, BMI calculation, Tanner pubertal stages and bone age assessment by the TW3 method. These, completed by clinical data about diagnosis, growth hormone deficiency treatment, and menarche in girls, were compared to the...
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Quantification of differences in ossification zones hand TW3 method in patients with hypothyroidism - the possibility of diagnostic use
Daniš, Robert ; Sedlak, Petr (advisor) ; Čermáková, Ivana (referee)
The assessment of the development of skeletal maturation is an essential diagnostic tool in many pediatric disciplines, especially in pediatric endocrinology. The most accurate method of estimating bone age (KV) is a method of Tanner-Whitehouse 3 (TW3), which separately evaluates compartments RUS and CARP, the ossification is controlled by different hormonal axes. While the file type of long bones (metacarpals, phalanges of fingers and distal epiphysis of the radius and ulna - system RUS) is under the dominant influence of somatotropic axis, in the regulation of the development of carpal bones (system CARP) dominates the influence of thyroid axis. The proportionality developmental retardation of the two compartments from the chronological age can directly show the suspected endocrine cause of growth and developmental disorder. The study included 48 patients with subclinical form of hypothyroidism or in eufunctional status and a reference group of 65 patients with idiopathic growth hormone deficiency and 53 children with constitutional delay of growth and development. All patients were from pediatric ambulances of the Institute of Endocrinology in Prague, ranging in age from 4-18 years. Differences were observed in the value of KV RUS/CARP, height and chronological age and midparental and TW3...
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