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Metabolic specifics of persons with increased risk of developing type 2 diabetes mellitus
 Chocholová, Denisa ; Vejražková, Daniela (advisor) ; Krejčí, Hana (referee)
Diabetes mellitus type 2 (DM2) is a metabolic disorder characterized by elevated blood glucose levels. The issue of the disease and its prevention is very topical, with the increasing prevalence of obesity in recent years leading to a constant rise in newly diagnosed individuals, with predictions for 2030 estimating up to 11 % of the world's population. The aim of the thesis is to evaluate the dynamics of glucose processing during a 3-hour oral glucose tolerance test (OGTT) in individuals at increased risk of developing DM2 and in a control group of healthy individuals with consideration of intersex differences. Information inherent in the glycemic trajectory could be significant both in terms of predicting potential glycemic dysregulation and other health complications such as dyslipidemia and other components of the metabolic syndrome (MS). It could thus contribute to extending the time interval suitable for very early and therefore more effective prevention. Furthermore, the thesis evaluates certain gene variants that may increase the risk of developing DM2. In this context, the genes MTNR1B and NME7 were investigated. A total of 1262 individuals (1035 women and 227 men) with various degrees of glucose tolerance underwent the extended 3-hour OGTT. Participants were examined in terms of...
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