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The optimization of fenbendazole extraction from environmental samples
Brodská, Denisa ; Matoušková, Petra (advisor) ; Raisová Stuchlíková, Lucie (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Denisa Brodská Supervisor: doc. Ing. Petra Matoušková, Ph.D. Consultant: Mgr. Martina Navrátilová Title of bachelor thesis: The optimization of fenbendazole extraction from environmental samples Anthelmintics are drugs used for the treatment and prophylaxis of infectious diseases caused by parasitic worms. In the Czech Republic, they are mainly used in veterinary medicine. During the biotransformation of the active substance, metabolites are formed, which are excreted together with the parent substance in faeces and urine. Fenbendazole and other similar substances can be absorbed into the soil in this way and subsequently act on non-target organisms in the environment. Fenbendazole is widely used in livestock farming, and since animal excrements are often further used for fertilization, the risk of the content of medicinal substances should be strictly monitored. For this purpose, it was necessary to develop and optimize the extraction method and also to carry out the corresponding validation of the analytical method, which will subsequently be applicable to real samples in the environment. The assumption of absorption of fenbendazole and its metabolic products, fenbendazole sulfoxide and...
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