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The serotonin transporter gene - polymorphism incidence study.
 Bílá, Nikola ; Macek, Milan (advisor) ; Goetz, Petr (referee)
Serotonin (5-hydroxytryptamine; 5-HT) is a neurotransmitter in the central and peripheral nervous systems. Serotonin transporter 5-HTT plays an important role in serotogenic transmisssion and the serotonin transporter gene is under investigation in connection with multiple psychiatric disorders. Three polymorphisms, an insertion/deletion and SNP in the promoter region and a variable nucleotide tandem repeat (VNTR) in intron 2, influence expression of the 5-HTT gene. We examined these polymorphisms at the serotonin transporter protein locus (SLC6A4) in three specific and representative cohorts drawn from the Czech population. These cohorts were stratified according to their age: a) randomly selected elderly individuals (over 75 years of age), b) young adults (age ranging between 19- 45 years) and c) newborns, all with balanced gender representation. The two regions were amplified and resolved on a 2% agarose gel and/or analyzed using the capillary electrophoresis in order to discriminate lenght polymorphisms. SNP in intron 2 was examined by RFLP after using MspI restriction. This analysis revealed that elderly individuals were statistically more likely than controls to carry two copies of the L allele of the lenth polymorphism. This may be due to the protective character of L allele, which is associated with...
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