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Group sequential tests in clinical trials
 Jílek, Josef ; Kulich, Michal (advisor) ; Komárek, Arnošt (referee)
Group sequential tests are an important statistical method. The analysis of data are performed continuously, which allows us to terminate the test before all observations are collected. For example these tests are used in medicine. When testing new drugs or procedures, this method brings about financial savings as well as ethical advantages. There are many ways of conducting group sequential tests with different qualities. Based on the perused literature, both basic and more complex types of group sequential tests are introduced in this paper. It discribes their principle and respective examples are provided. With this information it is possible to design and conduct a particular test. It's merits and demerits are compared for every method in real situations. The result is a tabular scale of different tests, from which it is possible to select a particular test for a given situation.
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