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Group sequential tests in clinical trials
Jílek, Josef ; Kulich, Michal (advisor) ; Komárek, Arnošt (referee)
Group sequential tests are an important statistical method. The analysis of data are performed continuously, which allows us to terminate the test before all observations are collected. For example these tests are used in medicine. When testing new drugs or procedures, this method brings about financial savings as well as ethical advantages. There are many ways of conducting group sequential tests with different qualities. Based on the perused literature, both basic and more complex types of group sequential tests are introduced in this paper. It discribes their principle and respective examples are provided. With this information it is possible to design and conduct a particular test. It's merits and demerits are compared for every method in real situations. The result is a tabular scale of different tests, from which it is possible to select a particular test for a given situation.
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Application of Integrated Library System Aleph 500 in academic libraries in Czech Republic
Jílek, Josef ; Stöcklová, Anna (advisor) ; Drobíková, Barbora (referee)
The master thesis describes and evaluates application of Integrated Library System Aleph 500 (in following text ILS Aleph) in academic libraries in Czech Republic. First chapter describes theoretical requirements at automated library systems for academic libraries. Apart of general requirements are described new technical trends as tools of Web 2.0. Second chapter brings full description of ILS Aleph with specification of each system's module. Third chapter is dedicated to implementation of ILS Aleph in Czech academic libraries. Characteristic of each institutional implementation contains three parts: characteristic of institution, describing of implementation and description of institutional OPACs. Last chapter is dedicated to empiric study of application of ILS Aleph in academic libraries in Czech Republic. ILS Aleph users are examined at three levels (library users, librarians, system administrators). Empiric study was made at group of Prague academic libraries that implemented ILS Aleph.
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Production of component the Cage ECR 10 12
Jílek, Josef ; Heinl, Tomáš (referee) ; Žák, Ladislav (advisor)
The thesis focuses on the production concept of component Cage ECR 10 12, which is used as assembly element together with a nut during the bus production. Sheet metal part is made from 11 321 steel 1,5 mm thick in production 10 000 parts per year. Technology of production in progressive tool was selected based on literature study. Progressive tool combines technology of shearing and bending. Tool was designed after the technological calculations. Forming machine was selected after the stamping force calculation. Eccentric press LEN 63 C with 630 kN forming force was selected for production.
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Effect of regulation on OTC derivatives in G-SIBS in the USA in 2010-2015
Zajíčková, Tereza ; Jílek, Josef (advisor) ; Munzi, Tomáš (referee)
Institutions from the G-SIBs category have been under greater scrutiny not just by regulatory authorities since the beginning of the financial crisis in 2008. Insufficient regulation in OTC derivatives combined with moral hazard expressed in the highly speculative behaviour by G-SIBs were major factors contributing to the development of the financial crisis. The regulatory bodies in the USA responded to the situation by adopting the Dodd-Frank ACT with the aim to introduce additional rules for the market with OTC derivatives and regulate the activities of G-SIBs significantly. The paper analyses selected indicators related to the OTC derivative exposure and the overall financial condition of the selected G-SIBs. The thesis analyses the development of the monitored indicators following the implementation of the DFA to confirm that the risk arising from speculative derivative deals by G-SIBs was reduced, the financial condition of the selected institutions was strengthened, and the systemic risk was thus suppressed during the period 2010-2015.
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Trolley for manipulation
Jílek, Josef ; Nevrlý, Josef (referee) ; Brandejs, Jan (advisor)
This Bachelor thesis deals with solution of interoperative material transport and design of trolley for manipulation of flooring rolls. The trolley was designed with the aim to increase safety and simplify the manipulation. It is simple welded frame made of metallurgical products. The trolley was designed to transport rolls with weight about 150 kg. Factor of safety was 23,5. It means that the construction of frame is well-dimensioned. This thesis also includes complete drawing documentation
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Group sequential tests in clinical trials
Jílek, Josef ; Kulich, Michal (advisor) ; Komárek, Arnošt (referee)
Group sequential tests are an important statistical method. The analysis of data are performed continuously, which allows us to terminate the test before all observations are collected. For example these tests are used in medicine. When testing new drugs or procedures, this method brings about financial savings as well as ethical advantages. There are many ways of conducting group sequential tests with different qualities. Based on the perused literature, both basic and more complex types of group sequential tests are introduced in this paper. It discribes their principle and respective examples are provided. With this information it is possible to design and conduct a particular test. It's merits and demerits are compared for every method in real situations. The result is a tabular scale of different tests, from which it is possible to select a particular test for a given situation.
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Application of Integrated Library System Aleph 500 in academic libraries in Czech Republic
Jílek, Josef ; Stöcklová, Anna (advisor) ; Drobíková, Barbora (referee)
The master thesis describes and evaluates application of Integrated Library System Aleph 500 (in following text ILS Aleph) in academic libraries in Czech Republic. First chapter describes theoretical requirements at automated library systems for academic libraries. Apart of general requirements are described new technical trends as tools of Web 2.0. Second chapter brings full description of ILS Aleph with specification of each system's module. Third chapter is dedicated to implementation of ILS Aleph in Czech academic libraries. Characteristic of each institutional implementation contains three parts: characteristic of institution, describing of implementation and description of institutional OPACs. Last chapter is dedicated to empiric study of application of ILS Aleph in academic libraries in Czech Republic. ILS Aleph users are examined at three levels (library users, librarians, system administrators). Empiric study was made at group of Prague academic libraries that implemented ILS Aleph.
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Integrated library system in libraries of ČVUT in Prague
Jílek, Josef ; Buřilová, Marcela (advisor) ; Stöcklová, Anna (referee)
Bakalářská práce popisuje a hodnotí Integrovaný knihovní systému Aleph 500 (IKS Aleph) v systému knihoven Českého vysokého učení technického v Praze (ČVUT). Úvodní část stručně pojednává o vývoji automatizace. Druhá část charakterizuje současný stav systému knihoven ČVUT, organizační strukturu, poskytované služby a zkušenosti s automatizací knihovních procesů a softwarem Automatizovaná knihovna. Následuje popis IKS Aleph a základní vymezení jeho funkcí. Čtvrtá kapitola je věnována hodnocení IKS Aleph jako automatizovaného knihovního systému pro vysoké školy. Závěrečná část popisuje proces implementace IKS Aleph v knihovnách ČVUT a vymezení specifik této implementace.
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Efektivnost monetární politiky při nulových sazbách
Mandok, Denis ; Jílek, Josef (advisor) ; Munzi, Tomáš (referee)
This thesis explores efficiency of monetary policy under zero lower bound condition. At first, is defined a role of monetary policy and criteria to judge the effectiveness of monetary policy are introduced. Then reactions of central banks of USA, Japan and Euro zone are explored. Thesis found out that monetary policy can be effective under a condition of zero lower bound. As last is introduced idea how to improve current monetary regime.
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The impact of quantitative easing on public sector bond yields of selected countries since 2007
Nacházel, Jan ; Jílek, Josef (advisor) ; Pekárek, Štěpán (referee)
This thesis deals with the impact of quantitative easing on public sector bond yields of selected countries in the world. It mentions channels of standard monetary policy tools and channels of quantitative easing, which can be included among unconventional monetary policy tools. This thesis analyses the impacts of quantitative easing, which was done by the Federal Reserve System, the Bank of England and the European Central Bank. Firstly, all these institutions fought against the financial crisis with standard monetary policy tools. However, those tools were not very effective, therefore the institutions moved to non-standard tools. After the analysis based on event-study method was carried out, it was found out that mainly the first announcements about the policy of quantitative easing were always the most effective in decreasing government bond yield. The subsequent expansion of the policy of quantitative easing did not have such impact. The main benefit of this thesis is in the examination of the impact of later statements regarding quantitative easing on government bond yield, which were not effective in decreasing government bond yield.
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