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Influence of glutamate-induced obezity on antioxidant enzymes in mice
 Duchačová, Kateřina ; Boušová, Iva (advisor) ; Matoušková, Petra (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Kateřina Duchačová Supervisor: doc. PharmDr. Iva Boušová, Ph.D. Title of diploma thesis: Influence of glutamate-induced obezity on antioxidant enzymes in mice. Obesity is currently one of the most widespread chronic diseases in the world. Many scientific teams are trying to clarify the causes of this disease and also examine changes in the body that may be related to this disease. The aim of this study was to determine the activity and expression of the enzymes superoxide dismutase (SOD) and catalase (CAT) and to assess activity of peroxidase (Px) in liver cytosol of experimental NMRI mice with obesity induced by monosodium glutamate (MSG) and healthy controls. Activities and expressions of selected enzymes were compared with respect to the pathological conditions (MSG mice, osmolality controls and unaffected mice), age (8 weeks x 20 weeks) and sex of the experimental mice. Activities were determined using spectrophotometric methods and polyacrylamide gel electrophoresis followed by immunoblotting was employed to monitor protein expressions. Differences in specific activities of SOD and CAT among the groups were only small. The most significant changes related to the induction of obesity...
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