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Phenotypic assessment of patients with severe chronic obstructive pulmonary disease by HRCT of the lung (Prospective analysis of patients in National Database of COPD)
 Kočová, Eva ; Eliáš, Pavel (advisor) ; Heřman, Miroslav (referee) ; Marel, Miloslav (referee)
Phenotypic assessment of patients with severe chronic obstructive pulmonary disease with using HRCT of the lung Aim Chronic obstructive pulmonary disease (COPD) is very important societal and economic problem worldwide. The main risk factor form COPD is tabacco smoke. CODP patients are very heterogenic group with different clinical symptoms. Due to different dominant clinic symptoms it is important to sort out patients to different groups - phenotypes. However differentiation into phenotype groups is not unified. Also using computed tomography (CT) in COPD diagnosis is not routine. The aim of this study is to assess if CT should be one of the basal paraclinic method used in diagnosis of all COPD patient. Materials and methos Patients from Czech multicentre research database of severe COPD which is registered on www.clinicaltrials.gov with number NCT01923051were analysed. The analysis of CT scans with clinical symptoms and lung functional tests was performed. Results From May 2013 were 784 patients included to the database. Completelly 359 patients had CT examination and lung functional tests. More than two thirds of patients (69,4 %) were dyspnoeic even during walk on level ground. Most of the patients were i GOLD group C and D. We have found bronchiectasis on CT in 120 (37,4 %), lung emphysema in...
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