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Assesment of diagnostic methods for immunologically based skin diseases
Brodská, Petra ; Pizinger, Karel (advisor) ; Arenberger, Petr (referee) ; Skořepová, Magdalena (referee)
Background: Atopic dermatitis is a common chronic inflammatory skin disease. Numerous IgE-inducing allergens play role in the pathogenesis of atopic dermatitis. Malassezia, the predominant skin microbiota fungus, is considered to exacerbate atopic dermatitis, especially in a subset of patients with head and neck type. In the present study the relationship between atopic dermatitis and sensitization to Malassezia antigens was investigated. Methods: We assessed 240 patients with atopic dermatitis seen at the Department of Dermatology, University Hospital in Zürich, Switzerland and at the Department of Dermatovenereology, University Hospital in Pilsen, Czech Republic. The subgroup of patients with primarily head, neck and upper torso pattern of atopic dermatitis was considered as HNAD type. Severity of eczema was assessed with EASI in Switzerland and with SCORAD in the Czech Republic. Total serum IgE and specific IgE to Malassezia were determined and correlated with clinical picture of atopic dermatitis, gender, age and severity of eczema. Results: Total IgE was elevated in 72.5% of patients. Specific IgE to Malassezia was positive (≥ 0.35 kU/l) in 54.2% of patients. Men were significantly more often sensitized to Malassezia antigen (63.5% of men versus 47.1% of women, p-value 0.013). Concurrently, patients...
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