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Pharmacological treatment of sclerosis multiplex
 Martincová, Petra ; Štaud, František (advisor) ; Červený, Lukáš (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Mgr. Petra Martincová Supervisor: Prof. PharmDr. František Štaud, Ph. D. Title of diploma thesis: Pharmacology treatment of multiple sclerosis Multiple sclerosis is a neurological inflammatory disease of central nervous system of an autoimmune origin with several subtypes according to different clinical courses. The main philosophy of a treatment is based on an early administration of anti-inflammatory treatment. This can delay irreversible neurodegeneration and disability of patients. In treatment of an acute symptomatic attack which may develop at any stage of disease methylprednisolone is most often administered. Long-term therapy is based on immunomodulatory drugs: interferon-β and glatiramer acetate. This treatment is intended for parenteral administration and reduces both the number of attacks and disease progression. However its effect is insufficient in most patients. For escalation of treatment some cytostatics may be used however they have many side effects. The first oral product registered in the Czech Republic is fingolimod. It is used for treatment of remitting form of multiple sclerosis and has a very good pharmaceutical effect. A new option in treatment is provided...
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