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Breast cancer cell population. Its usage for setting of optimal therapeutical regimen. Predictive model.
Kolařík, Dušan ; Halaška, Michael (advisor) ; Kofránek, Jiří (referee) ; Dundr, Pavel (referee)
1 ABSTRACT Background Breast cancer cell population characteristics are used in common clinical practice for estimation of prognosis of the malignant disease (prognostic factors) and for prediction of reactivity of the tumor to certain therapeutic modality (predictive factors). Also axillary lymph node status is an independent prognostic factor in women with early breast cancer. Therefore, surgical excision and following histopathological examination of the nodes is the obligatory part of primary breast cancer surgery. The extension of axillary surgery varies widely, although sentinel lymph node biopsy is considered to be the standard procedure. However, it must be admitted that this type of procedure need not be optimal for all the breast cancer patients. Aims of the study The aim of this study is the verify the hypothesis whether or not the axillary lymph node metastatic affection can be effectively estimated using non-surgical methods - i.e. by evaluation of the combination of prognostic and predictive factors of the primary breast tumor. Statistical model composed on the basis of data of early breast cancer patients is the basic tool for this prediction. Application of this model In everyday practice can enable to adjust the extent of axillary surgery for each individual patient. Patients and methods A...
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Breast cancer cell population. Its usage for setting of optimal therapeutical regimen. Predictive model.
Kolařík, Dušan ; Halaška, Michael (advisor) ; Kofránek, Jiří (referee) ; Dundr, Pavel (referee)
1 ABSTRACT Background Breast cancer cell population characteristics are used in common clinical practice for estimation of prognosis of the malignant disease (prognostic factors) and for prediction of reactivity of the tumor to certain therapeutic modality (predictive factors). Also axillary lymph node status is an independent prognostic factor in women with early breast cancer. Therefore, surgical excision and following histopathological examination of the nodes is the obligatory part of primary breast cancer surgery. The extension of axillary surgery varies widely, although sentinel lymph node biopsy is considered to be the standard procedure. However, it must be admitted that this type of procedure need not be optimal for all the breast cancer patients. Aims of the study The aim of this study is the verify the hypothesis whether or not the axillary lymph node metastatic affection can be effectively estimated using non-surgical methods - i.e. by evaluation of the combination of prognostic and predictive factors of the primary breast tumor. Statistical model composed on the basis of data of early breast cancer patients is the basic tool for this prediction. Application of this model In everyday practice can enable to adjust the extent of axillary surgery for each individual patient. Patients and methods A...
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Progress in the care of gerontopsychiatric in - patients
Schwarzerová, Pavlína ; Mellanová, Alena (advisor) ; Prošková, Eva (referee)
The bachelor thesis Development of care for gerontopsychiatric patients deals mainly with the development of nursing care at the gerontopsychiatric admission department of the Psychiatric Hospital Kosmonosy. The thesis describes the history of the psychiatric hospital and the establishment of gerontopsychiatric department. Other chapters describe the development of department equipment, the number of nursing staff, therapy regimen over twenty years and specifics of nursing care. Patient diagnoses leading to admission to Gerontopsychiatric departments are also described. The next section describes the development of nursing care at the department. It mainly deals with the process of patient admission, nursing care and documentation, staff approach to patients and relatives. My personal experience will certainly be reflected in the thesis because I have worked at the Gerontopsychiatric department for twenty years. The aim of this thesis is to find out what changes have occurred over twenty years. Therefore, considerable changes which I found out will be described and possible future development of gerontopsychiatry will be outlined in the conclusion. Key words: gerontopsychiatry, history, dementia, nursing care, therapeutic regimen
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