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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Long-term monitoring of ctDNA levels in patients with metastatic colorectal cancer for early detection of progression or recurrence of the disease
 Kopalová, Dominika ; Benešová, Lucie (advisor) ; Kološtová, Katarína (referee)
Circulating tumor DNA (ctDNA) in peripheral blood of patients with metastatic colorectal cancer appears to be a promising molecular marker that provides various applications. ctDNA levels vary depending on the presence, alternatively on the volume of tumor mass within patient's body, which can be used primarily for early detection of disease progression or recurrence and moreover for evaluating radicality of surgical treatment, all within long-term postoperative follow-up of the patient. Due to minimal invasivity of ctDNA analysis from peripheral blood (so-called liquid biopsy), it is possible to perform it repeatedly at relatively short time intervals. On account of very low fraction of ctDNA in total cell-free DNA (cfDNA) ranging between units and hundreds of percent, the key factor is optimal methodology covering all steps from the isolation process to a sufficiently sensitive detection technology. In this thesis I focus on an optimization of isolation process and analysis of ctDNA obtained from tumor tissue and plasma of selected patients with metastatic colorectal cancer in connection with surgical radicality and correlation with a clinical status of the patients.
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Circulating tumor DNA in advanced colorectal carcinoma patients
 Kopalová, Dominika ; Benešová, Lucie (advisor) ; Saláková, Martina (referee)
Colorectal carcinoma (CRC) is worldwide known as one of the most often tumor diseases. Approximately 50 % of patients are diagnosed with advanced stage of CRC and moreover even after removing all of the tumor bearings, there is high risk of its recurrence. As most of others solid tumors the CRC also releases fragments of DNA also known as the circulating tumor DNA (ctDNA). The ctDNA analysis is a new tool for monitoring continuous tumor burden and for observing treatment response. Due to its minimal invasivity and high specificity is suitable for instance for long period postoperative follow-up of patients with CRC. Within the long period follow-up process an evaluation radicality of operation is conducted as well as an early detection of new tumor foci. This thesis focus on an origin and releasing mechanism of ctDNA into bloodstream, its features and clinical utility options for patients with an advanced colorectal carcinoma. Key words: circulating tumor DNA, ctDNA, advanced colorectal carcinoma, mCRC, marker
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