|
|
Validation of a new method for the evaluation of stress relaxation of tablets
Černá, Pavlína ; Řehula, Milan (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Supervisor: Doc. RNDr. Milan Řehula, CSc. Title of Dissertation: Validation of a new method for the evaluation of stress relaxation of tablets Keywords: tablets, stress relaxation test, elastic and plastic deformation The theoretical part of this thesis deals with the elastic relaxation of tablets. It describes various methods used in the evaluation of elastic recovery of tablets. The present work explores the factors affecting the elastic relaxation of tablets. The experimental part is focused on the stress relaxation test. Until present only one delay was studied. This work studies the stress relaxation after relieving tablet. The parameters A2, T2 and P2 were reviewed. The relationship between the parameters P2 and compression force relief were studied. For experiments microcrystalline cellulose Avicel PH 102 (MCC) was used. Tablets were compressed in a device used for testing the strength of the material in pressure and tension T1-FRO 50. For the determination of the stress relaxation test, the tablets were compressed with 180 sec first delay. The second delay was always 60 sec but it was measured from certain decrease of pressure (7 kN, 6 kN, 5 kN, 4 kN, 3 kN, 2 kN, 1 kN and 0.1 kN). To...
|
|
|
Effect of acetylsalicylic acid on the parameters of compression equation
Šmíd, Jakub ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Jakub Šmíd Consultant: Doc. RNDr. Milan Řehula, CSc. Effect of acetylsalicylic acid on the parameters of compression equation Compacting process can be expressed mathematically by compression equations. It is characterized by various parameters. The compression equation expresses the dependence of the volume, density and height on compacting pressure. This paper evaluates the parameters of the compaction equation and study pre-loading phase, the phase of elastic deformation and the phase of plastic deformation. This thesis examines effect of acetylsalicylic acid on the parameters of compaction equation. Tablets were compressed from five mixtures. Mixtures contained acetylsalicylic acid and microcrystalline cellulose in different ratios 0:100, 25:75, 50:50, 75:25 and 0:100. The results were obtained using the three-exponential equation. Evaluation was carried out by using box plots.
|
|
|
Effect of ibuprofen on the parameters of compression equation
Tisoňová, Zuzana ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Tisoňová Zuzana Consultant: Doc. RNDr. Milan Řehula, CSc. Compacting process is mathematically expressed by compression equations. It is characterized by various parameters of equations. The equation expresses the dependence of the volume, density and height on compacting pressure. In this paperwork, the parameters of compacting equation are evaluated and the pre-loading phase, the phase of elastic deformation and the phase of plastic deformation are studied. This thesis deals with impact of ibuprofen on the parameters of compaction equation. Five mixtures which included microcrystalline celulose and ibuprofen in different ratio 100:0, 75:25, 50:50, 25:75 and 0:100 were studied. Results were based on the three-exponential equation. They were evaluated thanks to box plots. From the results obtained, it is obvious that with decreasing amount of microcrystalline cellulose, the parameter a1 has increased and the parameter E1 also slightly has increased. The composition of the used material didn't have any huge influence on parameters 1/t1 and pH1. During the phase of elastic deformation, the parameters a2 and E2 with decreasing amount of ibuprofen have decreased. On the other hand, the...
|
|
|
Effect of ascorbic acid on the parameters of compression equation
Pribylincová, Natália ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Natália Pribylincová Consultant: Doc. RNDr. Milan Řehula, CSc. Effect of ascorbic acid on the parameters of compression equation Many mathematical models describing the compressing process are widely used in the development of new medicinal products in form of tablets. This process can be evaluated by means of compaction equations or throughout the viscoelastic properties. Compaction equation expresses dependency on height, volume or density of the used material which is being compressed by the applied compacting pressure. Based on the gained parameters, it is possible to describe specifically various stages of the compaction process, to determine characteristic properties of the studied material and accordingly to examine its mechanism. This thesis deals with the impact of the ascorbic acid on the parameters of compaction equation. The paperwork evaluates a mixture consisting of ascorbic acid (AA) and microcrystalline cellulose (MCC) in the ratio of MCC : AA 100:0, 75:25, 50:50, 25:75, 0:100. . The mostly used compression equations are described in the theoretic part. The three - exponential equation by Řehula created at the Department of Pharmaceutical Technology at Charles...
|
|
|
Historical development of media didactics and its scope in the Czech Republic
Huspeková, Markéta ; Wolák, Radim (advisor) ; Zezulková, Markéta (referee)
The main goal of the thesis is to describe the development and the extent of media didactics in the Czech republic. The authors who examine media pedagogy are PhDr. Jan Mašek, Ph.D. a Mgr. Zdeněk Sloboda. The subject of the thesis is to clarify the concept of media didactics. This is important for the formation of historical development of the use of media during the teaching and for highlight the importance of media during the teaching and teaching with the use of media. Finally, the thesis try to find out the effects and the extent of tablets in the czech education system. By using quantitative questionnaire research was examined 200 teachers of primary schools, secondary schools and grammar schools. Based on the acquired data is possible to answer predetermined research questions: How widespread is the use of tablets during the teaching? What is the opinion of teachers to use tablets during the teaching? Does the use of tablets during the teaching influence the effectiveness of the teaching?
|
|
|
Graphic design of mobile application and mobile website
Fausek, Roman ; Šedivá, Zuzana (advisor) ; Pražský, Petr (referee)
This thesis describes process of developing fully responsive websites. It is focused on decision-making process for selecting the right online presentation of the project or company, individual pitfalls and creation. Creation is then demonstrated on a fully responsive website that relies on knowledge gained in the theoretical part. The goal is to focus on individual differences of mobile devices and their software in conjunction with the development of applications and websites. The output is fully responsive web based on gained experiences from the theoretical part.
|
|
|
Education with help of ICT tools
Hruška, Matyáš ; Očenášek, Vladimír (advisor) ; Radek, Radek (referee)
This thesis deals with the usage of ICT tools in education. It aims to find out which tools are used in modern teaching methods and what are the demands for teachers and students. In the first part is general description of ICT, which is used in education in both terms of hardware and software. The second part describes the precise implementation of these ICT tools in teaching at two schools that were observed. Both schools are using mobile touch devices during classes, however both schools are using different classroom format. The differences between these formats are explained further in the thesis and the use of ICT tools at both schools is explained with the help of practical examples. The work also deals with the issue of funding, especially from EU funds, from which one of the observed schools draws finances.
|
|
|
Ebooks and their creation
Kijkova, Eugenie ; Krejčová, Iva (advisor) ; Vlnas, Pavel (referee)
The bachelor thesis deals with area of electronic books. It deals with history of the industry and compares positives and negatives of electronic books versus classic books from the viewpoint of the authors as well as readers. It further analyses most frequently used formats in the Czech Republic and the way DRM is being applied against illegal transmission. It analyses different types of hardware used for reading electronic books and compares advantages and disadvantages of them. Also it informs about programmes suitable for editing, reading and management of electronic library. The practical part introduces tutorial how to work with Calibre software in terms of creation of electronic library, format conversion and synchronization of electronic books into e-reader. The main objective of the thesis is to provide complex insight into electronic books in current Czech market and introduction of effective ways of working with electronic books.
|
|
|
Czech Electronic Book Market – Obstacles and Opportunities
Šperková, Lucie ; Koubský, Petr (advisor) ; Brodský, Jiří (referee)
This master dissertation "Czech Electronic Book Market -- Obstacles and Opportunities" analyzes Czech market with e-books. The aim is to provide a comprehensive overview of the current situation on the market in terms of technologies, distribution models and legal issues. It describes commercial, free and illegal sources in the market, including a description of digitisation projects in Czech libraries. The thesis also includes a theoretical introduction to e-books and their development in the past. Details are discussed, focusing on technology, modern electronic readers with electronic ink. For comparison, the thesis also analyzes the U.S. market with e-books. In analytical part the individual portals with e-books on the market, their supply and user interfaces are compared. The real example analyzes the costs of an e-book and its comparison to costs of a printed book. At the end of the thesis, alternative models of distribution requirements for establishment of a new portal with e-books are characterised, the Creative Commons licenses are described and the current trend of e-journals is mentioned. Finally, I suggest recommendations especially for sellers on the Czech market describe the advantages and disadvantages of e-books in terms of individual roles in the distribution model and estimate the future market development. More detailed information related to the comparison of different types of electronic ink, a list of electronic readers that are available on the Czech e-book market at this time and specific examples of various users' interfaces that are being used on Czech e-books portals can be found in Appendix.
|
|
|
Electronic publications
Cahlík, Ondřej ; Bruckner, Tomáš (advisor) ; Burkoň, Lukáš (referee)
This thesis focuses on electronic publications for e-book readers. In its first part it aims at actual questions, current situation and expected trend in the field of electronic publishing, tablets and e-book readers based on e-ink technology. The other part of thesis is practical and focused on detailed conception and realization of the project for publishing student periodical publications -- Studentský list and Economix -- electronically at the University of Economics, Prague.
|
guest ::
