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Analysis of antibiotic prophylaxis in patients with osteosynthesis of proximal femur
Baťková, Anna ; Malý, Josef (advisor) ; Rejmanová, Anna (referee)
Analysis of antibiotic prophylaxis in patients with osteosynthesis of the proximal femur Author: Anna Baťková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Markéta Dlouhá Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: This work is part of the continuous monitoring of antibiotic prophylaxis (AP) at the Department of Traumatology, University Hospital. The aim was to analyze and compare key parameters of AP in osteosynthesis of pertrochanteric fractures with the previous investigation and the methodological guidelines of the University Hospital. Methods: This retrospective cross-sectional study took place from 1st April 2019 to 31st March 2020 at the Department of Traumatology at the University Hospital. AP was analyzed in 50 patients above 18 years of age and who underwent a pertrochanteric fracture of the proximal femur. Data was collected with a form, prepared in cooperation with the Department of Medical Microbiology, physicians and clinical pharmacists of the University Hospital. Information on the patient, surgery, indication of AP, selected antibiotic/chemotherapeutic (ATB) and its dose, time, route of administration, as well as the size, number and interval of administered postoperative doses and...
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Evaluation of clinical pharmacists interventions in the hospital
Veličková, Zuzana ; Doseděl, Martin (advisor) ; Malá, Kateřina (referee)
EVALUATION OF CLINICAL PHARMACIST'S INTERVENTIONS IN THE HOSPITAL Author: Zuzana Veličková Supervisor of the thesis: PharmDr. Martin Doseděl, Ph.D. Charles University, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy BACKGROUND The Drug-Related Problem is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes.i Pharmaceutical care deals with management of DRPs and its goal is to decrease occurrence of DRP. AIMS The aim of the study was to describe and evaluate the most common DRPs occurring in the selected department in the hospital. DRPs have been detected during reviews of pharmacotherapy by the clinical pharmacist. METHODS The study was carried out in the hospital in Šumperk, at the department of the internal medicine, the nursing section. Data was collected from medical records of hospitalized patients. Patient's characteristics (age, gender), diagnosis, using drugs, selected laboratory markers and drug- related problems were recorded. DRPs have been identified during reviews of the clinical pharmacist. Description and evaluation of DRPs contain its management, acceptation of pharmacist's intervention, evaluation of clinical severity and cost benefit of intervention. The classification of DRPs was...
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Analysis of the therapy in patients with juvenile idiopathic arthritis
Procházková, Martina ; Malý, Josef (advisor) ; Rozsívalová, Petra (referee)
Abstarct Analysis of the Therapy in Patients with Juvenile Idiopathic Arthritis Author: Martina Procházková Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Methotrexate (MTX) is an effective and safe drug used for the treatment of juvenile idiopathic arthritis (JIA) and is well-known like a golden standart in the treatment of this serious illness. The aim of this study was analysis of therapy in patients with JIA focusing on MTX and faktors affecting its intolerance. Methods: The study was undertaken from January 2017 to February 2018 at the Department of Paediatrics and Adolescent Medicine, 1st Faculty of Medicine, Charles University in Prague. Patients younger than 18 years old, who have become ill with JIA for the first time or repeatedly between years 2015-2017 and were treated by MTX were included in this study. The prevalence of MTX intolerance was measured by "Methotrexate Intolerance Severity Score" questionaire every 3 months during regular rheumatological examinations. Simultaneously, medical records were reviewed. Data analysis was performed by means of descriptive statistics, correlation dependence and statistical signifikance of dependence was assessed with statistical two-choice...
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Analysis of drug-related problems in a healthcare facility V.
Truongová, Thu Thao ; Doseděl, Martin (advisor) ; Malá, Kateřina (referee)
ANALYSIS OF DRUG-RELATED PROBLEMS IN A HEALTHCARE FACILITY V. Author: Thu Thao Truongová Supervisor of the diploma thesis: PharmDr. Martin Doseděl, Ph.D. Consultant: PharmDr. Veronika Měrková Charles University, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy INTRODUCTION Medication errors are one of the most frequent medicinal errors. They affect patient's safety from the long-term point of view.1 The great part of medication errors occurs on the level of drug administration.2 In healthcare facilities mostly nurses are responsible for medication administration.3 AIM To obtain and evaluate medication errors during drug administration by nurses in a healthcare facility. METHODICS A prospective observational study was conducted in the facility Hamzova léčebna for children and adults focusing on medical rehabilitation. Data collection was performed in May 2019 three consecutive days on each ward, where drugs were administrated by nurse. Direct observation was done in morning, noon and evening drug administrations. Obtained data were recorded into prepared form and were compared with physician's medication order on the patient's record. Afterwards, the forms were transcripted into online database, data were transfered to MS Excel software programme and evaluated by...
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Analysis of drug-related problems in a health facility I.
Bahnerová, Michaela ; Malý, Josef (advisor) ; Matoulková, Petra (referee)
Analysis of drug-related problems in a health facility I. Author: Michaela Bahnerová1 Tutor: Josef Malý1 1 Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Intoduction: Drug-related problems (DRPs) lower the quality of health care and present a risk factor in patient's safety. Objectives: The aim of this thesis is identification, classification and further analysis of DRPs in health care facility. Methods: Revision of pharmacotherapy was performed in health care facility in term 6. 8. - 10. 8. 2012. The pharmaceutical team which contained two pharmacists and diplomant examined health documentation of patients hospitalized in the facility. We collected information from personal, allergic, family, and labor-social anamnesis of patients. This data were noted into electronical database and after revision were DRPs classified and evaluated. The results of DRPs identification were evaluated by frequency analysis. In ten randomly selected patients was described DRPs resolution. Results: In total we noticed medical therapy in 175 patients (61 % women). Average patient's age was 58 years. 482 DRPs were identified. Of the patients, 84 % had DRPs and an average of 2,75 DRPs were recorded per patient. Conclusion: Appearance of DRPs is very frequent and...
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Analysis of antibiotic administration in prophylaxis II.
Bobčíková, Martina ; Malý, Josef (advisor) ; Rozsívalová, Petra (referee)
Analysis of antibiotic administration in prophylaxis II Author: Martina Bobčíková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Anna Patková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: The term antibacterial prophylaxis (AP) refers to antibiotic (ATB) administration in prevention of surgical site infection (SSI). There are many factors in population which can potentially raise the risk of the incidence of SSI. The maintenance of basic rules of the AP and knowledge, influence and timely elimination of risk factors of SSI are the most important measures which can reduce a number of postoperative SSI. The aim of this study was to analyze antibiotic administration in prophylaxis in the local hospital in the Czech Republic and compare the results to well known international guidelines (ASHP-G) and latest scientific knowledge (LSK). Methods: The cross-sectional study was conducted in October 2019. During the period from 2nd to 23rd October, the data of surgeries and used AP were collected. The patients who passed the entry criteria have been included in this study. Into prepared form, patient's identification, agreement, diagnosis, surgery type, operation date, the beginning and the end of surgery,...
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Analysis of drug-related problems in outpatients II.
Sperottová, Šárka ; Doseděl, Martin (advisor) ; Malá, Kateřina (referee)
Analysis of drug-related problems in general practitioners office II. Author: Šárka Sperottová Supervisor of the thesis: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Background: A Drug-Related Problem - DRP - is according to Pharmaceutical Care Network Europe - PCNE - an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. We can encounter DRP in every general practitioner's - GPs - office all around the world. But with proper cooperation between practitioners and pharmacists we could reduce the number of problems. That would be big benefit for patients and health system as well. This thesis is focused on anticoagulant drugs, mainly on DOAC group - direct oral anticoagulants - and their DRP in it's theoretical part. Practical part of thesis is analysis of DRP in GPs office itself. Aim: Theoretical part - describe the process of haemostasis and the possibilities of influencing this process by drugs. Discuss DRP of anticoagulants, especially oral anticoagulants and heparins. Practical part - identify and describe DRP. Sort them by PCNE Classification for DRP V5.01. Analyse and describe the most frequent drug-related problems occurring in general...
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Analysis of drug-related problems in a healthcare facility VI.
Záleská, Kristína ; Doseděl, Martin (advisor) ; Malá, Kateřina (referee)
Title of thesis: Analysis of drug-related problems in a healthcare facility VI. Candidate: Kristína Záleská Supervisor: PharmDr. Martin Doseděl, PhD. Department: Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Background and aim: A drug-related problem (DRP) has been defined as an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes [1]. The theoretical background chapter is aimed to give a detailed description of selected studies dealing with drug-related problems in various settings. The retrospective cross- sectional study, described in the experimental part of the thesis, was carried out in order to identify, classify and assess DRPs in a rehabilitation facility and to discuss the results with a physician and subsequently determine intervention acceptance rate. Methods: The data were collected during a nine-day-long audit in three wards of a rehabilitation facility in the Czech Republic through a review of medical documentation. The detected DRPs were classified using the modified version of PCNE classification v5.01 and their severity was assessed on a scale of 0 to 5. The DRPs were subsequently discussed with physicians and the pharmaceutical intervention acceptance rate was...
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Analysis of antibiotic administration in prophylaxis I.
Domecký, Petr ; Malý, Josef (advisor) ; Matoulková, Petra (referee)
8 Abstract Analysis of antibiotic administration in prophylaxis I Author: Petr Domecký Tutor: PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Lucie Hauschke, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Antibiotic prophylaxis (AP) plays an important role in reduction of surgical site infection (SSI). It is the administration of an eligible antibiotic or chemotherapeutic (ATB) in a single dose, usually 30 minutes before surgery, followed by two to three doses during or after the surgery, regarding the selected ATB and the surgical procedure. The aim of this work was to analyse the AP in surgical procedures at the Masaryk Hospital in Ústí nad Labem (MNUL) in the context of the MNUL guideline (DP) and the research on available AP work. Methods: A cross-sectional observational study ran from January 2018 to March 2018 in surgical departments at MNUL. The study included patients aged ≥ 18 years who underwent surgery in a defined period (5 February 2018 to 9 February 2018) and gave their consent to the study. The practicability of the study was verified by a pilot part. Initially, a research of published studies concerning AP was carried out which provided outputs for AP establishment (PPA). Subsequently, a form for...
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