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Studium bioaktivace vybraných proléčiv
Vernerová, Monika ; Kovaříková, Petra (advisor) ; Kastner, Petr (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Monika Vernerová Supervisor: Assoc. Prof. PharmDr. Petra Kovaříková, Ph.D. Consultant: Kristiina Huttunen, Ph.D., School of Pharmacy, Faculty of Health Sciences, Kuopio, University of Eastern Finland Title of thesis: Bioactivation study of selected pro-drugs This thesis deals with an enzymatic bioactivation study of the valproic acid's pro- drug. The evaluation was based on the data obtained from the HPLC analysis with appropriate method. The incubation reactions were carried out in a presence of different biological tissues, but also with isolated enzymatic fractions. The half-life of each bioactivation reaction was calculated from the gained results. It was also observed, if the bioconversion of the pro-drug to the parent drug, valproic acid, had been occured. These in vitro results will help to analyse samples from following in vivo experiments and help in designing better pro-drugs in future.
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The Crime of Perjury and False Expert Report according to Section No. 346 of the Criminal Code
Vernerová, Monika ; Zeman, Pavel (referee)
The Crime of Perjury and False Expert Report according to Section No. 346 of the Criminal Code Abstract A great deal of media attention has been dedicated recently to cases of experts facing the charge of perjury and false expert report pursuant to Section No. 346 of Act No. 40/2009 Coll. of the Criminal Code (hereinafter referred to as the Criminal Code). These cases reduce the experts' credibility in the eyes of the public, cast doubts on their practice as a whole and are therefore commonly used as an argument for adopting a new Law on the experts' conduit. In accordance with the aforementioned facts, the goal of this thesis is to provide a further insight into the crime of perjury and false expert report under Section No. 346 of the Criminal Code. The thesis consists of an introduction, five chapters and a conclusion. The first chapter gives a historical overview concerning perjury and false expert report followed by the definition of Section No. 346 of the Criminal Code, including its specific elements, and finally an analysis of several disputed cases that call into question the conclusion of criminal liability under Section No. 346 of the Criminal Code, such as the expert's consultant, the processor of the expertise or the formal and the material witnesses. The following chapter is divided into two...
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The Crime of Perjury and False Expert Report according to Section No. 346 of the Criminal Code
Vernerová, Monika ; Zeman, Pavel (referee)
The Crime of Perjury and False Expert Report according to Section No. 346 of the Criminal Code Abstract A great deal of media attention has been dedicated recently to cases of experts facing the charge of perjury and false expert report pursuant to Section No. 346 of Act No. 40/2009 Coll. of the Criminal Code (hereinafter referred to as the Criminal Code). These cases reduce the experts' credibility in the eyes of the public, cast doubts on their practice as a whole and are therefore commonly used as an argument for adopting a new Law on the experts' conduit. In accordance with the aforementioned facts, the goal of this thesis is to provide a further insight into the crime of perjury and false expert report under Section No. 346 of the Criminal Code. The thesis consists of an introduction, five chapters and a conclusion. The first chapter gives a historical overview concerning perjury and false expert report followed by the definition of Section No. 346 of the Criminal Code, including its specific elements, and finally an analysis of several disputed cases that call into question the conclusion of criminal liability under Section No. 346 of the Criminal Code, such as the expert's consultant, the processor of the expertise or the formal and the material witnesses. The following chapter is divided into two...
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The Crime of Perjury and False Expert Report according to Section No. 346 of the Criminal Code
Vernerová, Monika ; Vokoun, Rudolf (advisor) ; Bohuslav, Lukáš (referee)
The Crime of Perjury and False Expert Report according to Section No. 346 of the Criminal Code Abstract A great deal of media attention has been dedicated recently to cases of experts facing the charge of perjury and false expert report pursuant to Section No. 346 of Act No. 40/2009 Coll. of the Criminal Code (hereinafter referred to as the Criminal Code). These cases reduce the experts' credibility in the eyes of the public, cast doubts on their practice as a whole and are therefore commonly used as an argument for adopting a new Law on the experts' conduit. In accordance with the aforementioned facts, the goal of this thesis is to provide a further insight into the crime of perjury and false expert report under Section No. 346 of the Criminal Code. The thesis consists of an introduction, five chapters and a conclusion. The first chapter gives a historical overview concerning perjury and false expert report followed by the definition of Section No. 346 of the Criminal Code, including its specific elements, and finally an analysis of several disputed cases that call into question the conclusion of criminal liability under Section No. 346 of the Criminal Code, such as the expert's consultant, the processor of the expertise or the formal and the material witnesses. The following chapter is divided into two...
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Studium bioaktivace vybraných proléčiv
Vernerová, Monika ; Kovaříková, Petra (advisor) ; Kastner, Petr (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Monika Vernerová Supervisor: Assoc. Prof. PharmDr. Petra Kovaříková, Ph.D. Consultant: Kristiina Huttunen, Ph.D., School of Pharmacy, Faculty of Health Sciences, Kuopio, University of Eastern Finland Title of thesis: Bioactivation study of selected pro-drugs This thesis deals with an enzymatic bioactivation study of the valproic acid's pro- drug. The evaluation was based on the data obtained from the HPLC analysis with appropriate method. The incubation reactions were carried out in a presence of different biological tissues, but also with isolated enzymatic fractions. The half-life of each bioactivation reaction was calculated from the gained results. It was also observed, if the bioconversion of the pro-drug to the parent drug, valproic acid, had been occured. These in vitro results will help to analyse samples from following in vivo experiments and help in designing better pro-drugs in future.
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