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	Study of gene expression regulation in kidneys. Trávníčková, Aneta ; Smutná, Lucie (advisor) ; Mladěnka, Přemysl (referee) Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Aneta Trávníčková Supervisor: PharmDr. Lucie Smutná, PhD. Title of diploma thesis: Study of gene expression regulation in kidneys During evolution, each organism was forced to create its complex defense system to prevent the accumulation of endogenous and foreign substances, including drugs, in the body. These defense systems are composed of Phase I and Phase II enzymes and transport proteins. One of the main roles in the metabolism of endogenous and biotransformation of exogenous substances is ensured by the constitutive androstane receptor (CAR). This work aimed to determine the effect of activation of the human constitutive androstane receptor (hCAR) on the gene expression of drug transporters and biotransformation enzymes in the kidneys of humanized mice. Additionally, to examine the effect of CAR on the expression of selected genes in the HK2 cell line. In both cases, the isolation of mRNA was performed using the classic phenol-chloroform extraction followed by reverse transcription and the qRT-PCR reactions. Firstly, we studied the influence of CITCO, an agonist of hCAR, on the expression of biotransformation and transport protein genes in the kidneys of humanized mice. The expression... Detailed record
	The Period of Work of Actor Miroslav Macháček on The Stage of České Budějovice. TRÁVNÍČKOVÁ, Aneta The aim of this bachelor thesis is the reconstuction of the actions of Miroslav Macháček in the role of actor and director in the theater in České Budějovice. Although this period represents a short time in Machaček?s profesional career, his work is signicifantly written in the history of the South Bohemian theater. In politicaly complicated situation of the second half of the twentieth century Macháček?s negative political attitude caused him various of professional and personal troubles. These circumstances created an interesting background in his work. Using available sources and information this thesis should give a comprehensive view of the work of Miroslav Macháček on the scene of the South Bohemian theatre. Detailed record
	The Fundamentals of Formation and Financial Management for a Project cofinanced by the EU Resources TRÁVNÍČKOVÁ, Aneta This thesis includes describing of basic problems by creation and financial management of projects cofinanced from EU sources. There is also a comparing of possible differences in the thematic operational programs. The rules governing this area are generally defined. However, their particular form is always in the context of every thematic operational program more stringent. In this thesis is created a model project budget completed by a draft of possible budget items accounts. Detailed record

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