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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Multivalentní glykomika v imunoterapii experimentálních nádorů
 Vannucci, Luca ; Pospíšil, Miloslav ; Krist, Pavel ; Křen, Vladimír ; Huliková, Katarína ; Luptovcová, Martina ; Svoboda, Jan ; Kuldová, Markéta ; Bezouška, Karel ; Rossmann, Pavel ; Difato, Francesco ; Mosca, F. ; Fišerová, Anna
Lectin-like receptors can modulate the cytotoxic, regulatory and dendritic cell responses by their interactions. GN8 multivalent glycoconjugates are able to internalize inside and activate NKR-P1 positive cells inducing production of IFN-gamma and expression of CD69. The final effect is a modulation of anticancer immunity with reduction of cancer growth
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Imunomodulační glykodendrimery mají afinitu k endoteliím nádorových a embryonálních cév. Mikroskopické průkazy a perspektivy využití
 Vannucci, Luca ; Fišerová, Anna ; Krist, Pavel ; Křen, Vladimír ; Huliková, Katarína ; Luptovcová, Martina ; Rossmann, Pavel ; Difato, F. ; Mosca, F. ; Pospíšil, Miloslav
Glycodendrimers coated with N-acetyl-glucosamine and labeled with a fluorescent dye demonstrate special tropism to neogenerated endothelia in cancer capillaries. Same distribution was observed by confocal microscopy in the new vessels of rat embryo abdominal wall, as in placenta and yolk sack endothelia. Results suggests the presence of a commun target on evoluting endothelia, the nature of which is under investigation.
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