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Homology search using digital signal processing methods
Kamar, Yana ; Jugas, Robin (referee) ; Maděránková, Denisa (advisor)
Thesis includes the theoretical introduction to molecular biology and genetics on the necessary level, including a description of the structure of DNA and the homologous gene. Described are fixed and physic-chemical kinds of nucleotide mapping, methods for processing digital signals. Numerical representations of genes that were programmed in MATLAB: unwrapped and accumulated phases, density vectors. Using the unwrapped phase and density vectors with windows of different lengths was performed CDS searching in the entire genome by calculation metric distances (euclidean and canberian) and correlation. Also, using the metric distances, a homologous gene was found in more or less similar bacterial genomes. The result is the approximate threshold of distance (euclidean and canberian) using to find homologous genes in genome.
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Classification and analysis of retinal blood vessel pulsations
Kamar, Yana ; Kolář, Radim (referee) ; Odstrčilík, Jan (advisor)
This diploma thesis deals with the pulsation of the vascular bed on the retina. The goal was to automatically extract the pulsation curve (venous and arterial) from the fundus video, to find the diagnostically significant parameters of these curves and to propose algorithm for evaluating the parameters. The following method was chosen for venous pulsation: the area of the vessel and its surroundings was automatically selected inside the optical disc, the brightness of this area was averaged. For arterial: the brightness of the background of the vessels around the optic disc is averaged. Research was conducted on the topic of parameters to which the work will be devoted. The result is a set of pulse curves of both types. Conducted examination of the parameters of these curves (specifically amplitude). It is also possible to examine the phase shift of the curves relative to each other.
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Classification and analysis of retinal blood vessel pulsations
Kamar, Yana ; Kolář, Radim (referee) ; Odstrčilík, Jan (advisor)
This diploma thesis deals with the pulsation of the vascular bed on the retina. The goal was to automatically extract the pulsation curve (venous and arterial) from the fundus video, to find the diagnostically significant parameters of these curves and to propose algorithm for evaluating the parameters. The following method was chosen for venous pulsation: the area of the vessel and its surroundings was automatically selected inside the optical disc, the brightness of this area was averaged. For arterial: the brightness of the background of the vessels around the optic disc is averaged. Research was conducted on the topic of parameters to which the work will be devoted. The result is a set of pulse curves of both types. Conducted examination of the parameters of these curves (specifically amplitude). It is also possible to examine the phase shift of the curves relative to each other.
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|
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Homology search using digital signal processing methods
Kamar, Yana ; Jugas, Robin (referee) ; Maděránková, Denisa (advisor)
Thesis includes the theoretical introduction to molecular biology and genetics on the necessary level, including a description of the structure of DNA and the homologous gene. Described are fixed and physic-chemical kinds of nucleotide mapping, methods for processing digital signals. Numerical representations of genes that were programmed in MATLAB: unwrapped and accumulated phases, density vectors. Using the unwrapped phase and density vectors with windows of different lengths was performed CDS searching in the entire genome by calculation metric distances (euclidean and canberian) and correlation. Also, using the metric distances, a homologous gene was found in more or less similar bacterial genomes. The result is the approximate threshold of distance (euclidean and canberian) using to find homologous genes in genome.
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