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Synthesis and oxidative coupling of 1,5-disubstituted tetrazoles
 Hrušková, Zuzana Rania ; Pour, Milan (advisor) ; Špulák, Marcel (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Zuzana Rania Hrušková Supervisor: Prof. RNDr. Milan Pour, PhD Title of diploma thesis: Preparation and oxidative coupling of 1,5-disubstituted tetrazoles. Following the established protocol developed for the preparation of 1,5-disubstituted tetrazoles employing Pd-catalyzed cross-coupling reactions with activated the C5-H bond we have been able to extend the existing library of tetrazoles. 1,5-Disubstituted tetrazoles were used as substrates for oxidative coupling reactions which would result to formation of tetrazolo[1,5-f]phenathridine core. However, all of the common methods we used for this reaction lead only to the traces of the desired product.
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