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Adhesivity and Viscosity of the Branched Oligoesters
Bacílková, Anna ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
Theoretic part deals with theories of bioadhesion, characteristics of bio- and mucoadhesives. Routs of application are analysed in more detail. Theoretic part is concluded with testing of bioadhesion. Experimental part of thesis investigates rheological and adhesive properties of plasticized oligoesters of D,L - lactic acid and glycolic acid in ratio 1:1 branched with pentaerythritol or tripentaerythritol. Adhesivity was measured on the Material testing machine T1-FR050TH.A1K Zwick/Roell as maximal force Fmax required to detach the polymer system from substrate. These values were converted to the size of the contact area. Viscosity of samples was measured using viscosimeter Brookfield DV-E with an adaptor for small sample amount by 37řC and 50řC temperature. From the outcomes of made experiments follow that carriers with higher molar mass possess higher dynamic viscosity, the lowest dynamic viscosity was found at carrier with the lowest molar mass. The lowest adhesive force was found at carrier 1P with relative low degree of branching g'= 0,59 and middle molar mass Mw = 8400 g/mol. Adhesivity of other carriers was significantly higher, in range from 49.26 mN/mm2 to 65.97 mN/mm2 . Acyclovir release from branched carriers differs particularly at initial phase. Carrier 3P with the digest molar mass...
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Metabolic Profile of Panax ginseng Bioactive Substance in Plant Material of Varies Origin.
Bacílková, Anna ; Klusoňová, Hana (advisor) ; Havlík, Jaroslav (referee)
Author: Anna Bacílková Title: Metabolic profiles of bioactive components of Panax ginseng C. A. Meyer from different herbal sources Diploma thesis Publishing place: Charles University in Prague, Faculty of Pharmacy in Hradec Králové The field of study - pharmacy In this diploma thesis, I was concerned with the determination and quantification of 12 ginsenosides in 11 commercial ginseng preparations from the species Panax ginseng C. A. Meyer available in the Czech Republic. Ginsenosides are triterpenes saponins considered to be main bioactive principles of ginseng. The two-dimensional thin layer chromatography and high performance liquid chromatography with UV detection was used for the identification and quantitative determination of these compounds. The methods applied are based on comparison of the retention times and retention factors of samples and a mixture of standards. The content of ginsenoside Rf was used as a marker to differentiate Panax ginseng C. A. Meyer from other species. Ginsenosides were detected only in 8 from 11 preparations. There was also significant product-to-product variability in concentrations and proportions of ginsenosides. The content of ginsenosides was also compared with available data from manufacturer and the measured concentrations of marker compounds differed...
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Adhesivity and Viscosity of the Branched Oligoesters
Bacílková, Anna ; Dittrich, Milan (referee) ; Šnejdrová, Eva (advisor)
Theoretic part deals with theories of bioadhesion, characteristics of bio- and mucoadhesives. Routs of application are analysed in more detail. Theoretic part is concluded with testing of bioadhesion. Experimental part of thesis investigates rheological and adhesive properties of plasticized oligoesters of D,L - lactic acid and glycolic acid in ratio 1:1 branched with pentaerythritol or tripentaerythritol. Adhesivity was measured on the Material testing machine T1-FR050TH.A1K Zwick/Roell as maximal force Fmax required to detach the polymer system from substrate. These values were converted to the size of the contact area. Viscosity of samples was measured using viscosimeter Brookfield DV-E with an adaptor for small sample amount by 37řC and 50řC temperature. From the outcomes of made experiments follow that carriers with higher molar mass possess higher dynamic viscosity, the lowest dynamic viscosity was found at carrier with the lowest molar mass. The lowest adhesive force was found at carrier 1P with relative low degree of branching g'= 0,59 and middle molar mass Mw = 8400 g/mol. Adhesivity of other carriers was significantly higher, in range from 49.26 mN/mm2 to 65.97 mN/mm2 . Acyclovir release from branched carriers differs particularly at initial phase. Carrier 3P with the digest molar mass...
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Metabolic Profile of Panax ginseng Bioactive Substance in Plant Material of Varies Origin.
Bacílková, Anna ; Havlík, Jaroslav (referee) ; Klusoňová, Hana (advisor)
Author: Anna Bacílková Title: Metabolic profiles of bioactive components of Panax ginseng C. A. Meyer from different herbal sources Diploma thesis Publishing place: Charles University in Prague, Faculty of Pharmacy in Hradec Králové The field of study - pharmacy In this diploma thesis, I was concerned with the determination and quantification of 12 ginsenosides in 11 commercial ginseng preparations from the species Panax ginseng C. A. Meyer available in the Czech Republic. Ginsenosides are triterpenes saponins considered to be main bioactive principles of ginseng. The two-dimensional thin layer chromatography and high performance liquid chromatography with UV detection was used for the identification and quantitative determination of these compounds. The methods applied are based on comparison of the retention times and retention factors of samples and a mixture of standards. The content of ginsenoside Rf was used as a marker to differentiate Panax ginseng C. A. Meyer from other species. Ginsenosides were detected only in 8 from 11 preparations. There was also significant product-to-product variability in concentrations and proportions of ginsenosides. The content of ginsenosides was also compared with available data from manufacturer and the measured concentrations of marker compounds differed...
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