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Intrinsic viscosity and interfacial tension of solutions polyester and polyesteramides drug carriers
Šanderová, Martina ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Viscosity and interfacial tension of the solutions of polyesters and polyesteramides carriers of drugs. Student: Mgr. Martina Šanderová Tutor: Assoc. Prof. Dr. Milan Dittrich, PhD. Depart od Pharmaceutical Technology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic Surface activity and intrinsic viscosity of the solutions of various carriers of the type of polyesters and polyesteramides were studied. The theoretical part of the thesis is focused on the basic informations concerning viscosity as phenomenon, surface activity of the solutions of polymers, biodegradable polymers and their properties, and polyesters of aliphatic hydroxyacids. In the experimental part of the thesis was evaluated viscosity and interfacial tension of the solutions of various carriers in chloroform used as solvent. Interfacial tension was measured by Wilhelmy plate method, and intrinsic viscosity was calculated from kinematic viscosity, from their one-point values, by the Solomon-Ciuta method. All the studied oligomeric and polymeric carries were tensioactive. Interfacial tension between aqueous and chloroform phases was influenced by molecular weight of the used compounds, their degree of branching, by flexibility of their chains and their concentracion also. Calculated values of...
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Viscosity and surface activity of polyester carriers solutions
Šanderová, Martina ; Dittrich, Milan (advisor) ; Šklubalová, Zdeňka (referee)
Viscosity and surface activity of the solutions of polyester carriers Student: Martina Šanderová Tutor: Assoc. Prof. Dr. Milan Dittrich, PhD. Department of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic This dissertation targets the viscosity research and the surface activity research of the solutions of polyester pharmaceutical carriers. In the theoretic part of this work we generaly disserted upon the viscosity, upon the surface and the intersurface tension, upon the biodegradable polymers and polyesters of aliphatic hydroxyacids. In the experimental part of this persuit we disserted on measurement and on evaluation of kinematic viscosity and the intersurface tension of different concentrated solutions of linear copolymers of the glycolic acid and D,L-lactic acid or of branched terpolymers of the glycolic acid and D,L-lactic acid. The forked adduckts were mannitol and three pentaerytritols with multiply units of quantity. Chloroform was used as solvent. For measurement of the intersurface tension was used the measuring method with using the platinum plate in accordance with Wilhelm. The results will may be used at the formulation optimalization of biodegradable preparations of the monolithic or particulate type.
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Intrinsic viscosity and interfacial tension of solutions polyester and polyesteramides drug carriers
Šanderová, Martina ; Šnejdrová, Eva (referee) ; Dittrich, Milan (advisor)
Viscosity and interfacial tension of the solutions of polyesters and polyesteramides carriers of drugs. Student: Mgr. Martina Šanderová Tutor: Assoc. Prof. Dr. Milan Dittrich, PhD. Depart od Pharmaceutical Technology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic Surface activity and intrinsic viscosity of the solutions of various carriers of the type of polyesters and polyesteramides were studied. The theoretical part of the thesis is focused on the basic informations concerning viscosity as phenomenon, surface activity of the solutions of polymers, biodegradable polymers and their properties, and polyesters of aliphatic hydroxyacids. In the experimental part of the thesis was evaluated viscosity and interfacial tension of the solutions of various carriers in chloroform used as solvent. Interfacial tension was measured by Wilhelmy plate method, and intrinsic viscosity was calculated from kinematic viscosity, from their one-point values, by the Solomon-Ciuta method. All the studied oligomeric and polymeric carries were tensioactive. Interfacial tension between aqueous and chloroform phases was influenced by molecular weight of the used compounds, their degree of branching, by flexibility of their chains and their concentracion also. Calculated values of...
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