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National Repository of Grey Literature

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Evaluation of the pharmacological properties of new potential drugs for Alzheimer's disease Čechová, Pavlína ; Šorf, Aleš (advisor) ; Urbánková Rathouská, Jana (referee) Charles University Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Student: Pavlína Čechová Supervisor: PharmDr. Aleš Šorf, Ph.D. Consultant: mjr. PharmDr. Vendula Hepnarová, Ph.D. Title of diploma thesis: Assessment of pharmacological properties of new potencial drugs for Alzheimer's disease treatment Alzheimer's disease is a neurodegenerative disease with a progressive and irreversible course. The cause of AD is still not exactly known. There are currently four drugs available that have been approved by the State Institute for Drug Control. Three of them act as cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and the fourth one as a N-methyl-D-aspartate (NMDA) receptor antagonist (memantine). Unfortunately, these drugs do not affect the course of the disease and provide only temporary symptomatic relief. An important area of current research is MTDLs (Multi-Target Directed Ligands), which act on multiple target structures related to the pathophysiology of the disease. These agents represent a promising therapeutic strategy. The aim of the study was to measure the ability to inhibit human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) of 58 new potential MTDLs derived from biphenyl and benzhydryl using Ellman's method, as well as... Detailed record

The concept of death in the modernist literature. Studied on the example of Thomas Manns "Tristan", Arthur Schnitzlers "Sterben", and Hugo Von Hofmannsthals "Der Tor und der Tod" Čechová, Pavlína ; Markvartová, Eva (advisor) ; Broukalová, Jindra (referee) Detailed record

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