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DEEP LEARNING FOR SINGLE-VOXEL AND MULTIDIMENSIONAL MR-SPECTROSCOPIC SIGNAL QUANTIFICATION, AND ITS COMPARISON WITH NONLINEAR LEAST-SQUARES FITTING
Shamaei, Amirmohammad ; Latta,, Peter (oponent) ; Kozubek, Michal (oponent) ; Jiřík, Radovan (vedoucí práce)
Preprocessing, analysis, and quantification of Magnetic resonance spectroscopy (MRS) signals are required for obtaining the metabolite concentrations of the tissue under investigation. However, a fast, accurate, and efficient post-acquisition workflow (preprocessing, analysis, and quantification) of MRS is challenging. This thesis introduces novel deep learning (DL)-based approaches for preprocessing, analysis, and quantification of MRS data. The proposed methods achieved the objectives of robust data preprocessing, fast and efficient MR spectra quantification, in-vivo concentration quantification, and the uncertainty estimation of quantification. The results showed that the proposed approaches significantly improved the speed of MRS signal preprocessing and quantification in a self-supervised manner. Our proposed methods showed comparable results with the traditional methods in terms of accuracy. Furthermore, a standard data format was introduced to facilitate data sharing among research groups for artificial intelligence applications. The findings of this study suggest that the proposed DL-based approaches have the potential to improve the accuracy and efficiency of MRS for medical diagnosis. The dissertation is structured into four parts: an introduction, a review of state-of-the-art research, a summary of the aims and objectives, and a collection of publications that showcase the author's contribution to the field of DL applications in MRS.
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