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Study of some markers of human leukemia
Pospíšilová, Klára ; Jílek, Petr (advisor) ; Skálová, Lenka (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Study Field: zbioanalytical chemistry Candidate: Klára Pospíšilová Thesis Supervisor: PharmDr. P. Jílek, PharmDr. Consultant: RNDr. P. Řezáčová, MD., Ph.D., Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic Thesis Title: Study of some markers of human leukemia Abstract: Immunophenotyping of leukemia cells is an important part of leukemia diagnosis. Immunophenotype is determined by flow cytometry using monoclonal antibodies against antigens expressed by these cells. Antigen CD44 is one of many CD markers used in immunophenotyping of leukemias. Protein crystallography of a complex between CD44 antigen and its ligand, hyaluronate, bring more detailed information about the structure of the binding site, which may help develop strategies for influencing the binding and thus for potential therapeutic intervention.
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Thermodynamic Stability of Thaumasite
Pospíšilová, Klára ; Dvořák, Karel (referee) ; Fridrichová, Marcela (advisor)
This work deals with the resolution of the identification characteristics of the thaumasit, which falls into the same group of AFt phases as the mineral ettringit. Both of these stages have the same structural arrangement and the morphology. This work’s specific goal is the synthetic preparation of thaumasit in a variety of conditions and its evaluation.
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Motivation and Stabilization of Key Employees in Ceska zbrojovka a.s.
Pospíšilová, Klára ; Chovanec, Josef (referee) ; Rašticová, Martina (advisor)
This master thesis focuses on the problem of motivation, stimulation and stabilization of the key employees in the company Česká zbrojovka a.s. The main aim of this thesis is to identify insufficiencies in the current system of employee motivation and to suggest potential changes leading to its improvement and assessment from the economic impact of the proposed improvements to the company. The theoretical part of the thesis contains the fundamental knowledge and base of the human resources management and also discusses various theories of work motivation. Reviewed problems of demotivation and unwanted employee turnover follow. The practical part of the thesis shows a qualitative analysis of the current system of the staff motivation in Česká zbrojovka a.s. There is also linked and combined theoretical knowledge with the corporate practice. The final part of the thesis is based on facts found from the survey which identifies imperfections in the existing system and formulates potential recommendations for improving employee motivation and stabilization in the analysed company in order to improve work performance, enhance job satisfaction and loyalty of employees to Česká zbrojovka a.s.
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