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The relationship between selected inflammation markers and markers of the endothelial dysfunction to preterm labor and fetal inflammatory response
Koucký, Michal ; Hájek, Zdeněk (advisor) ; Krofta, Ladislav (referee) ; Živný, Jan (referee)
The doctoral dissertacion is focused on the role of inflammation in the pathogenesis of preterm labor. In the first part, we describe the current view on pathophysiology of preterm labor. In the second part, we evaluated the relationship of specific markers of inflammation and endothelial dysfunction to preterm birth and fetal inflammatory response. The most important findings of our study was that we found decreased levels of MMP-2 and decreased levels of sRAGE in women with preterm labor in comparison with the control group of pregnant women. Similarly, we found decreased levels of MMP-2 in women with subsequent diagnosed fetal inflammatory response. sRAGE is currently ranked among patttern recognition receptors. In the case of sRAGE we followed the results of our pilot project, it can be assumed that the its low level are connected with tissue damage. We confirmed that it can play an important role in the pathogenesis of preterm labor. We assume abnormal regulatory mechanisms of the production of MMP-2. In both cases, however, further studies are required to elucidate the functional significance of our results.
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National differences in obstetrics - care of a woman in labour from Vietnam.
Leová, Minh Thuy ; Hájek, Zdeněk (advisor) ; Šimonová, Daniela (referee)
The bachelor thesis deals with Vietnamese community, especially Vietnamese women. It contains of brief information about Vietnam and its culture. The thesis also describes the specific needs of Vietnamese woman during pregnancy, childbirth and puerperium. The thesis i salso involved in obstetrics in Vietnam which is different from czech obstetrics. Therefore, my aim was to find out whether Vietnamese women are satisfied with care during pregnancy and childbirth in the Czech Republic. What traditions and rituals are used in conection with prenatal, childbirth and postpartum periods, whether they are still adhered to even though they have been born in the czech republic or living here for a short time. Another aim was to find out whether the language barrier is the main problem during hospitalization between the vietnamese woman and the medical staff and how this barrier is solved. In the practical part quantitative research was carried out using a questionaire survey. I divided the respondents into two groups on vietnamese woman 1. and 2. generation. After that the data analysis was carried out and research showed that vietnamese woman rated prenatal care and the care in czech matertiny hospitals positively. Then vietnamese traditions and rituals were examined during pregnancy, childbirth and...
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Thrombophilia in pregnancy
Vítková, Magda ; Kvasnička, Jan (advisor) ; Hájek, Zdeněk (referee) ; Penka, Jaroslav (referee)
5 ABSTRACT Background: Thromboembolic disease is one of the most common causes of pregnant women morbidity and mortality. The pregnancy period is often the first time, when the apparent congenital or acquired thrombophilia is identi- fied. Patients with thrombophilia have an increased risk of pregnancy compli- cations. The optimal anticoagulant prophylaxis helps to prevent these compli- cations. Methods: The presented work is focused on monitoring of coagulation param- eters, blood counts and acute phase proteins in pregnant women (N = 68) with thrombophilia treated with enoxaparin during pregnancy and it is also con- cerned with evaluation of effectiveness of anticoagulant therapy during preg- nancy using anti FXa activity determination based on inhibition of FXa weight, coagulation parameters and acute phase proteins. In the first and the second part of the study, there is no control group of pregnant patients with severe thrombophilia, but no anticoagulation - this is justified by ethical rea- sons. In the third part, we examined by questionnaire our patients for enoxap- arin adverse reactions at the injection site. Finally, the last part is focused on evaluation of enoxaparin effects on bone remodelling markers, compared with a group of pregnant women without anticoagulation. Results: During the...
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The relationship between selected inflammation markers and markers of the endothelial dysfunction to preterm labor and fetal inflammatory response
Koucký, Michal ; Hájek, Zdeněk (advisor) ; Krofta, Ladislav (referee) ; Živný, Jan (referee)
The doctoral dissertacion is focused on the role of inflammation in the pathogenesis of preterm labor. In the first part, we describe the current view on pathophysiology of preterm labor. In the second part, we evaluated the relationship of specific markers of inflammation and endothelial dysfunction to preterm birth and fetal inflammatory response. The most important findings of our study was that we found decreased levels of MMP-2 and decreased levels of sRAGE in women with preterm labor in comparison with the control group of pregnant women. Similarly, we found decreased levels of MMP-2 in women with subsequent diagnosed fetal inflammatory response. sRAGE is currently ranked among patttern recognition receptors. In the case of sRAGE we followed the results of our pilot project, it can be assumed that the its low level are connected with tissue damage. We confirmed that it can play an important role in the pathogenesis of preterm labor. We assume abnormal regulatory mechanisms of the production of MMP-2. In both cases, however, further studies are required to elucidate the functional significance of our results.
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Development of iGoogle Applications
Hájek, Zdeněk ; Ščuglík, František (referee) ; Ráb, Jaroslav (advisor)
This thesis describes the iGoogle technology, analysis, design and developing of application for managing and tracking time spent on taks or projects. Thesis also involves interesting pieces of knowledge gathered during developing and by the end results of working with the iGoogle technology.
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Electricity Consumption Measuring Appliance
Hájek, Zdeněk ; Strnadel, Josef (referee) ; Šimek, Václav (advisor)
This thesis describes the designing and development of electricity consumption meter. First of all, a theoretical basis necessary for understanding a physical principle of measured subject is introduced. In the next part a suitable way of measuring in context of embedded devices is being looked for. Some of peripheral devices useful for project are described briefly. Then follows the detailed description of concept, that in the following part transforms to hardware design. Next part documents creation of the fi rmware. By the end of this thesis the project testing is described as well as the resume of gathered knowledge.
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Research of Equipment for Sea Water Treatment and Other Applications
Hájek, Zdeněk ; Klemeš,, Jiří (referee) ; Odstrčil, Miloslav (referee) ; Jegla, Zdeněk (advisor)
As water resources are rapidly being exhausted, more and more interest is focused on the desalination of sea water and brackish water. Increasing amounts of fresh water will be required in the future due to the rise in population rates, increasing living standards and the expansion of industrial and agricultural activities. The thesis is concentrated on current issues of treatment of sea water, mainly the desalination based on the distillation principle, in order to develop a unit for seawater treatment. The aim is to develop a compact modular unit for seawater desalinate on based on the implementation and evaluation of experimental tests on the experimental unit. The solution includes an overview of systems for treatment of seawater, a discussion of structural and material aspects of the units, design and manufacture of the experimental unit and confrontation the calculated values with the results of experimental measurements.
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Characteristic parameters of oxygen-enhanced combustion process
Hudák, Igor ; Hájek, Zdeněk (referee) ; Bělohradský, Petr (advisor)
Diplomová práce se zabývá spalováním zemního plynu při využití vzduchu s vyšším obsahem kyslíku (21–46 % kyslíku ve spalovacím vzduchu), tzv. kyslíkem obohaceným spalováním (OEC). Technologie OEC nalezla uplatnění v průmyslu, kde se jsou nároky na zvýšenou produktivitu, dosažení vyšší tepelné účinnosti, zlepšení vlastností plamene, snížení náklady, či zlepšení kvality výsledného produktu. Ačkoliv OEC přináší řadu výhod, je nutné zmínit i nevýhody jako: poškození zařízení, nestejnoměrné zahřívání, narušení plamene, zvýšené emise anebo zpětný zášleh plamene. Zkoušky proběhly na zkušebně hořáků, která umožňuje testovat hořáky nejen na plynná a kapalná paliva, ale i hořáky navržené pro kombinované spalování při maximálním výkonu hořáku 1 800 kW. Při zkouškách byl použit plynový „low-NOx“ hořák se stupňovitým přívodem paliva. V diplomové práci je popsán vliv obsahu kyslíku ve spalovacím vzduchu na emise oxidů dusíku (NOx), teplotu plamene, přenos tepla ze spalin do stěn spalovací komory, a také vlastnosti plamene, zvláště pak jeho stabilitu, tvar a rozměry. Zkoušky proběhly při výkonech 300 kW, 500 kW a 750 kW, přičemž pro výkon 750 kW proběhly testy jak při jednostupňové, tak dvoustupňové konfiguraci.
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Fossil fuels substitution in large combustion plant
Hájek, Zdeněk ; Popela, Pavel (referee) ; Touš, Michal (advisor)
The thesis aims at current issues of using renewable resources here in the Czech Republic, mainly on biomass co-firing with fossil fuels in large combustion plant. The introduction provides an overview of systems for biomass co-firing. Further the using of optimization for solution problem of integration biomass fuels into existing large combustion plants and planning its operation conditions is presented. The main point of this thesis lies in creating of a user interface for modeling and optimization tool. Its functionality will be proved by solving a case study involving the analysis of possibilities for replacing fossil fuels due to the limited availability of coal in the market.
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