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Syntéza 4'-N pyrrolidinových nukleosidů, nukleotidů a oligonukleotidů
Rejman, Dominik ; Kočalka, Petr ; Pohl, Radek ; Rosenberg, Ivan
Synthetic routes to novel pyrrolidine nucleoside, nucleotide, and oligonucleotide analogues, where C-4‘ carbon atom of ribose is replaced with nitrogen atom of pyrrolidine have been developed.
Nové nukleosidfosfonové kyseliny jako inhibitory thymidinfosforylázy
Kočalka, Petr ; Rinnová, Markéta ; Vaněk, Václav ; Rejman, Dominik ; Votruba, Ivan ; Tomečková, Ivana ; Králíková, Šárka ; Petrová, Magdalena ; Páv, Ondřej ; Pohl, Radek ; Buděšínský, Miloš ; Liboska, Radek ; Točík, Zdeněk ; Rosenberg, Ivan
Several sugar-modified thymine-containing nucleoside phosphonic acids were found as a strong inhibitors of thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain.
From nucleoside phosphonic acids to modified oligonucleotides
Rosenberg, Ivan ; Endová, Magdalena ; Králíková, Šárka ; Liboska, Radek ; Rejman, Dominik ; Točík, Zdeněk
A number of new isopolar phosphonate nucleotide analogues were prepared and a large set of oligonucleotides containing structurally diverse modification internucleotide linkages could be created.

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